This satellite symposium, Physiology of obesity and diabetes, shared insights from breaking research advances relevant to human obesity and type 2 diabetes from the basic science and clinical realms to better understand metabolic health.
Symposium organisers
Organiser: Lora Heisler, University of Aberdeen, UK
Co-organisers: Peter Aldiss, University of Birmingham, UK
Daniel Brayson, University College London, UK
Jo Lewis, University of Cambridge, UK
Sponsors
This satellite symposium is supported by Elsevier, The British Heart Foundation and British Society for Neuroendocrinology.
Welcome
Lora Heisler and Peter Aldiss
New insights into the genetic contributions of human adiposity
Chairs: Peter Aldiss, University of Birmingham and Jan Nedergaard, University of Stockholm
- 09:00 Opening Keynote: Genetic contributions of obesity
- Giles Yeo, University of Cambridge, UK
- 09:45 Genetic determinants of adipogenesis
- Justin Rochford, University of Aberdeen, UK
- 10:15 Regulation of food intake by brainstem astrocytes
- Kate Ellacott, University of Exeter, UK
Latest advances in behavioural contributions to body weight
Chairs: Dr Jo Lewis, University of Cambridge and Dr Gisela Helfer, University of Bradford
- 11:00 Impact of peripheral regulators of energy balance on the reward system.
- Suzanne Dickson, University of Gothenburg, Sweden
- 11:30 Impact of activity and inactivity on body weight
- Jason Gill, University of Glasgow, UK
- 12:00 FGF21 - a selective inhibitor of sugar and alcohol appetite
- Susanna Søberg, Novo Nordisk Foundation Center for Basic Metabolic Research, Copenhagen, Denmark (EYES invited talk)
- 12:15 Functional interrogation of caudal brainstem circuits modulating appetite
- Giuseppe D’Agostino, University of Aberdeen, UK
10 talks selected from abstracts (3 minutes, 3 slides each)
Chairs: Ian Salt, University of Glasgow and Rebecca Dumbell, MRC Harwell
- AMP-activated protein kinase (AMPK) activator R481 improves the counterregulatory response to hypoglycaemia by amplifying glucagon release in healthy rats
- Craig Beall, University of Exeter
- Repeated hypoglycaemia attenuates cFos expression in corticotrophin-releasing hormone neurons of the paraventricular nucleus of hypothalamus
- Adhithya Sankar, University of Manchester
- Blueberry extract supplementation prevents diet induced obesity in C57BL/6 mice fed a high-fat diet
- Alina Zitskaja, Rowett Institute
- A novel protein regulator of adipogenesis
- Pola Verschoor, University of Aberdeen
- Effects of two-weeks of time restricted feeding on basal and postprandial metabolism in healthy men
- Robert Jones, University of Nottingham
- Phenotypic screening reveals diverse gene expression signatures between different browning agents using high throughput Openarray qPCR in human adipocytes
- Graeme Davies, AstraZeneca
- Impact of carotid sinus nerve resection on metabolic dysfunction induced by ageing and by long-term hypercaloric diet consumption in rats
- Joana F. Sacramento, Universidade Nova de Lisboa
- Insulin sensitivity was enhanced by Ocimum gratissimum leaf extract in Wistar rats with dexamethasone-induced metabolic syndrome
- Shehu-Tijani Shittu, University of Ibadan
- Inhibition of chemerin/CMKLR1 axis in the hypothalamus reduces body weight and food intake
- Gisela Helfer, University of Bradford
- Osteoblast-specific Enpp1 deficiency engenders increased bone mass and insulin resistance
- Fiona Roberts, University of Edinburgh
Glucose sensing and glycaemic control
Chairs: Barbara Cannon, Stockholm University and Pablo Martinez de Morentin, University of Aberdeen
- 14:30 "Insulin resistance" and major disease - monogenic lessons
- Rob Semple, University of Edinburgh, UK
- 15:00 New targets for the treatment of type 2 diabetes
- Mirela Delibegovic, University of Aberdeen, UK
- 15:30 Islet (beta-cell) heterogeneity is essential for insulin secretion
- Daniela Nasteska, University of Birmingham, UK
- 15:45 Importance of GLP-1 axis post-bariatric surgery
- Pierre Larraufie, University of Cambridge, UK
Breaking advances in human metabolic disease treatment
- 16:30 Gut peptide combination therapy for the treatment of human obesity
- Tricia Tan, Imperial College London, UK
- 17:00 New medications in the pipeline for obesity and type 2 diabetes treatment
- Jacqueline Naylor, MedImmune, UK
- 17:30 Molecular Metabolism Early Career Researcher Prize
- Rebecca Dumbell, MRC Harwell Institute
- 17:50 Closing Keynote: Molecular mechanisms of islet function
- Lori Sussel, Barbara Davis Center for Diabetes, Colorado, USA
Closing remarks
Daniel Brayson and Jo Lewis
Location
The ‘Physiology of obesity and diabetes’ satellite sympsoium will be held at the Mercure Aberdeen Ardoe House Hotel, South Deeside Road Blairs, Aberdeen, AB12 5YP.