• 08 July - 10 July 2019
  • Aberdeen Exhibition and Conference Centre, Aberdeen, UK

Physiology 2019

Register here
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Physiology 2019

Our annual conference is The Society’s flagship event, and is your opportunity to hear the latest in physiology while catching up with friends and colleagues from around the world. Between 8 – 10 July 2019, we look forward to hosting you in the historic city of Aberdeen, where you will enjoy a warm Scottish welcome with first class science and unmissable networking opportunities.

Attending Physiology 2019? Head over to our key info page for travel and onsite registration information.

Physiology 2019 is supported by

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Download a pdf of the programme here.

Download a pdf of the abstracts here.

Monday 8 July 2019

Registration

Otto Hutter Teaching Prize Lecture

PL01 The perils and pleasures of educating 21st century physiology undergraduates

Julia Choate, Monash University, Australia

Boyd Suite

Symposia

Organiser: Holly Shiels, University of Manchester, UK
Co-organiser: Mark Miller, University of Edinburgh, UK

Summary:
Air pollution is responsible for several million premature deaths each year. It is associated with wide-ranging adverse cardiovascular effects that can culminate in heart attacks, strokes and irregular rhythms, particularly in people already at risk for these conditions. The mechanisms underlying cardiovascular toxicity are still incompletely understood. Additionally, interplay between airway, vascular and cardiac effects are unclear. Understanding the mechanisms by which air pollution induces cardiovascular dysfunction, and the interactions between routes of entry and pathophysiology are vital, particularly now as air pollution levels increase worldwide. This symposia will bring together clinical and fundamental scientists working on cardiac and vascular aspects of air pollutants to share recent advances in mechanistic understanding and therapeutic possibilities.

10:00
Paul Wilkinson, London School of Hygiene and Tropical Medicine, UK
10:30 SA001 The cardiotoxicity of phenanthrene
Charlotte Marris, University of Manchester, UK
10:45 SA002 From car to coronary: inhaled particles and the cardiovascular system
Mark Miller, University of Edinburgh, UK
11:00 SA003The greenwashing of fuels
Jenny Bosson, University of Umeå, Sweden

Organiser: Derek Scott, University of Aberdeen, UK

Summary:
Physiology is a practical subject, but it is also a flourishing discipline. This may mean classes attract students from a wide variety of academic backgrounds, some with only limited laboratory experience. The popularity of physiology may mean that teachers must balance a desire to deliver advanced practical physiology experiences against increasing class sizes and other logistical constraints. This symposium will highlight innovative approaches used in designing, delivering and assessing practical experiences in physiology.

Supported by ADInstruments

 

10:00 SA004 Teaching physiology using human-patient simulators
Richard Helyer, University of Bristol, UK
10:30 SA005 Technology-enhanced learning-by-doing: Inclusive experimental human physiology in Higher Education
Abigail Rickard, University of Greenwich, UK
10:45 SA006 Teaching physiology practical exercises, education solutions at the University of Antwerp
Marc Demolder, University of Antwerp, Belgium
11:00 SA007 Using invertebrate and plant model systems to teach physiology and experimental design in inquiry-based practical teaching
Dee Silverthorn, The University of Texas at Austin, USA

Organiser: Ewan Smith, University of Cambridge, UK
Co-organiser: David Bulmer, University of Cambridge, UK

Summary:
This symposium will bring together speakers who work on different aspects of pain, from ion channel biophysics to the role of the central nervous system in generating and maintaining pain. The overarching aim of the symposium is to provide a platform enabling researchers focused on different aspects of sensory processing and pain to come together in an effort to share new findings and establish new collaborations. Secondary aims are to disseminate findings from recent studies using exciting experimental methodologies, such as the power of combined retrograde tracing and single-cell RNA-sequencing, and the need for studying sex-dependent differences in pain processing.

For publication in The Journal of Physiology.

10:00 SA008 Why sodium channel Nav1.7 is required for pain sensation
John Wood, University College London, UK
10:30 Men and women are not the same – why we need to consider sex and pain
Katy Vincent, University of Oxford, UK
10:45 SA009 Single-cell RNAseq reveals seven classes of colonic sensory neuron
James Hockley, University of Cambridge, UK
11:00 SA010 Finding new analgesic targets – the long way round
Lucy Donaldson, University of Nottingham, UK

Oral Communications - Short talks

10:00 C061 Untargeted metabolomics using a novel bioinformatics approach for classification of human skeletal muscle ageing
Daniel Wilkinson, University of Nottingham, University of Nottingham, UK
10:15 C062 Effect of type 2 diabetes in muscle deoxygenation during ramp incremental exercise in older individuals
Adam McDermott, Trinity College Dublin, Ireland
10:30 C063 Effect of age on ankle proprioception
Zoe Djajadikarta, Neuroscience Research Australia, Australia
10:45 C064 Morphological alterations of mouse skeletal muscle during late maturation and early ageing are muscle specific
Guy Anselme Messa, Manchester Metropolitan University, UK
11:00 C065 Post-exercise hypotension and skeletal muscle oxygenation is modulated by nitrate-reducing activity of oral bacteria in healthy individuals
Raul Bescos, University of Plymouth, UK
11:15 C066 21-day ‘dry’ immersion of healthy people leads to reduction of baroreflex synchronization of heart rate and arterial pressure during orthostasis, similar to observed in patients with vasavagal syncope
Anatoly Borovik, Institute for Biomedical Problems, Russian Federation
10:00 C073 Treatment with the synthetic retinoid Fenretinide protects against fatty liver disease in LDLR-/- mouse model of atherosclerosis
Dawn Thompson, University of Aberdeen, UK
10:15 C074 Adiponectin inhibits contractile signalling via inhibition of Rho-associated protein kinase in human vascular smooth muscle cells
Ian Salt, University of Glasgow, UK
10:30 C075 A novel ex vivo and in silico approach to determine placental tissue oxygenation in normal and fetal growth restricted pregnancies
Gareth Nye, University of Chester, University of Manchester, UK
10:45 C076 Classification model for the detection of women at risk of preterm birth based on exosomal miRNAs and proteins in cervico-vaginal fluid at early gestation
Holly Jenkins, Kings College London, UK
11:00 C077 Preeclampsia Link to Hypoxic Pregnancy
Wen Tong, University of Cambridge, University of Cambridge, UK
11:15 C078 ATP reduces functional cell-to-cell tethering between renal tubular epithelial cell
Paul Squires, University of Lincoln, UK
10:00 C037 The effect of cystic fibrosis sputum on cystic fibrosis transmembrane regulator mediated Cl- transport and airway-surface-liquid height. Is gene editing sufficient to restore function in the cystic fibrosis environment?
Maximillian Woodall, St. George's University, London, UK
10:15 C038 Calcium entry through TRPC1 and ORAI1 regulates activated pancreatic stellate cells proliferation
Silviya Radoslavova, Université Picardie Jules Verne, INSERM U1003, Université de Lille, France
10:30 C039 Intracellular pH modulation in human umbilical vein endothelial cells requires sodium/proton exchangers activity in gestational diabesity but sodium/proton exchanger-1 activity in gestational diabetes with maternal pre-gestational normal weight or overweight
Luis Sobrevia, Pontificia Universidad Católica de Chile, Universidad de Sevilla, University of Queensland, Chile
10:45 C051 Bioelectrical control of axial regeneration in planaria flatworms
Ann Rajnicek, University of Aberdeen, UK
11:00 C041 Exploring the mechanism of inactivation of Kir7.1 K+ channel by snowflake vitreoretinopathy-associated mutation R162W
Francisco Sepulveda, Centro de Estudios Cientificos (CECs), Chile
11:15 C042 Nox-derived ROS in bladder urothelium – effect of inflammatory mediators and pathological significance
Josephine Amosah, University of Surrey, UK
10:00 C109 Association between vascular stiffness and oscillatory flow pattern in patients with recent Myocardial Infarction
Smriti Badhwar, All India Institute of Medical Sciences, New Delhi, India
10:15 C110 GPR81 activation causes endothelin-1 dependent renal vasoconstriction
Natalie Jones, BHF Centre for Cardiovascular Science, The University of Edinburgh, UK
10:30 C111 The effect of the small conducatance calcium-activated potassium channel (SK) inhibitor ICAGEN in intact atria and atrial cardiomyocytes
Sara Dobi, Institute of Cardiovascular and Medical Sciences, UK
10:45 C112 A Ca2+-regulated G protein (Rab46) couples inflammatory stimuli to differential trafficking of Weibel-Palade bodies
Lynn McKeown, University of Leeds, UK
11:00 C113 Involvement of M2 muscarinic receptors and Kv7 channels in cholinergic-mediated contractions of murine bronchial rings.
Tuleen Alkawadri, Dundalk Institute of Technology, Ireland
11:15 C114 Descending vasa recta pericytes mediate medullary no-reflow after renal ischaemia
Felipe Freitas, University College London, UK

Refreshment break

The Paton Prize Lecture

Lunch and professional development sessions

Summary:
An opportunity for early career physiologists to seek feedback on their CV from an experienced researcher and/or lecturer. Each session will be 15 minutes, and places will be allocated on a first-come first-served basis. To sign up, please send your CV to education@physoc.org by 1 July 2019, and indicate whether you would prefer a UK or non-UK reviewer, or someone with a research or teaching focus. If you submit your CV, please keep the hour free until you are assigned your time.

Your data will be processed in accordance with our Fair Processing Notice

Speaker panel:
Kim E Barrett, Editor-in-Chief of The Journal of Physiology
Mike Tipton, Editor-in-Chief of Experimental Physiology

Summary:
The goal of this session is to introduce postgraduate students, postdoctoral fellows, and early career investigators to some of the unwritten “dos and don’ts” of publishing. Armed with this information, you should be equipped to increase your chances of securing publication of your work in the journal of your choice while avoiding ethical minefields along the way. Although designed for early carer researchers, all are welcome. The content would be useful for senior researchers to disseminate to their teams.

Summary:
Lt is ADInstruments’ cloud-based online learning platform for Life Science education. We have over 340 interactive and customisable lessons across 9 collections, including Human Physiology, Animal Physiology and Neuroscience. Lt integrates with our teaching PowerLab hardware, to enable students to record physiological data and, once they’re finished, Lt will remember all the data, so they can login on their own device and finish their lesson at home.

In this session we will demonstrate Lt, taking you through one of our Human Physiology modules and show live recording of physiological data. We will show our grading tools by getting attendees to log in to Lt as a student and answer a series of MCQ’s – there will be a prize for our top student!

N.B. To participate in the quiz, you will need your own device (Laptop, Tablet or Phone) to access Lt.

Speaker panel:
Sadhana Sharma, BBSRC
Maja Wållberg, Wellcome Trust
Ashley Richardson, Abertay University

Summary:
This session provides the opportunity to hear directly from BBSRC the kind of examples and language that funders are looking for in terms of demonstrating impact as part of grant applications. To provide real-life examples of this, we will be joined by academics from a Sport and Exercise Science department that contributed to The Society’s recent report Sport & Exercise Science Education: Impact on the UK economy. Case studies highlighted will include examples of how physiological research can be translated into sustained student engagement with some of Scotland’s most deprived communities and work to improve individual health outcomes and reduce the economic cost associated with inactivity and poor diet.

Enter our Early Career Researcher kick-starter competition for a chance to win £1000 of funding for your research project!

We are pleased to announce that we will be running our kick-starter competition for Early Career Researchers for the second year running at Physiology 2019.  We welcome you to enter by visiting The Physiological Society Stand (#6) between 8th – 10th July to film a 30-60 second elevator pitch for your proposed project. All video entries will be reviewed, post-conference, by a panel of senior journal editors and a prize winner will be announced in the weeks following.

What is an elevator pitch?

Imagine you’re in a lift with the funder for research at your faculty. You have their undivided attention for 20 seconds – pitch your research idea for funding within that time, to see if you can convince them to help you kickstart your project.

What your pitch needs to cover…

What are you researching?
What are the challenges in your area of research?
What problem you are trying to solve?
Why is it important?
What will the funding enable you to do?

Terms and conditions apply, please see the Wiley staff on the day.

Symposia

Organiser: Johanna Lanner, Karolinska Institutet, Sweden
Co-organiser: Malcom Jackson, Liverpool University, UK

Summary:
Intramuscular free radicals (reactive oxygen/nitrogen species, ROS/RNS) comprises a double-edged nature; they appear beneficial for adaptations to endurance training, but also linked to muscle weakness and degeneration in several common diseases and in normal ageing. The speakers of this symposium are engaged in trying to understand the molecular and mechanistic details of ROS/RNS and how free radicals shifts between being protective and modulatory to damaging and detrimental, which is of interest both for athletes that want to perform better and in the search for novel therapeutics to counteract muscle weakness.

14:30 Oxidative stress and inflammation in ageing muscle
Anne McArdle, University of Liverpool, UK
15:00 SA015 Skeletal muscle redox signalling in rheumatoid arthritis
Maarten Steinz, Karolinska Institutet, Sweden
15:15 SA016 Role of redox signaling in skeletal muscle adaptations to training
Mari Carmen Gómez-Cabrera, University of Valencia, Spain
15:30 Reactive Oxygen Species (ROS) promote metabolic health and lifespan
Michael Ristow, ETH Zürich, Switzerland

Organiser: Deborah Baines, St George’s, University of London, UK

Summary:
Electronic nicotine delivery systems (ENDS), more commonly known as E-cigarettes, are used as a tobacco free nicotine delivery system. These devices utilise a liquid solution which is drawn over a heating element to produce a vapour which is then inhaled giving rise to the term ‘vaping’. The solution normally contains humectants to generate the vapour and act as carriers for nicotine and a wide range of flavourings.  E-cigarette usage has increased significantly in the past 10 years in former tobacco smokers and never smokers. However, E-cigarette devices and e-liquids remain unregulated. There is much debate around the safety of E-cigarettes and their benefit as a tool for quitting tobacco products and nicotine addiction. This symposium will provide new emerging information on the health impacts of E-cigarette use and their effect on airway physiology

For publication in The Journal of Physiology.

14:30 SA017 The smokefreebrain study: A multidisciplinary examination of e-cigarette toxicity
Tim Marczylo, Public Health England, UK
15:00 SA018 Physiologic effects of e-cigarettes on the cardiopulmonary system
Laura Crotty Alexander, UC San Diego School of Medicine, USA
15:15 SA019 The effect of e-cigarettes on susceptibility to pneumococcal infection
Lisa Miyashita, Queen Mary University of London, UK
15:30 SA020 What you don’t know can’t hurt you? The effects of E-cigarettes on the human lung
Robert Tarran, UNC School of Medicine, USA

Organiser: Bryan Taylor, University of Leeds, UK

Summary:
This symposium will highlight the multifaceted utility of exercise in the assessment and treatment of pulmonary hypertension (PH). We will discuss evidence from animal and computational models, and in humans that exercise training is safe and may improve pulmonary vascular function and pulmonary haemodynamics, attenuate maladaptive right ventricular hypertrophy and electrophysiological remodelling, increase exercise capacity, and enhance QoL in people with PH. We will also discuss the use of cardiopulmonary exercise testing (CPET) to uncover ‘silent’ pulmonary vascular pathology, and the ever-increasing role of CPET in the assessment of disease severity/progression and the tracking of responses to therapy in people with PH.

For publication in Experimental Physiology.

14:30 SA011 Optimizing exercise prescription for pulmonary hypertension: Insight gained from acute and chronic exercise studies in rodent models and in patients
Mary-Beth Brown, University of Washington, USA
15:00 SA012 Effects of voluntary exercise on cardiac remodelling and vulnerability to arrhythmia in rats with pulmonary hypertension
Al Benson, University of Leeds, UK
15:15 SA013 Pulmonary pressures during exercise: Comparing the healthy older adult to the pulmonary hypertension patient
Kirsten Coffman, United States Army Research Institute of Environmental Medicine, USA
15:30 SA014 Using exercise testing in the evaluation of pulmonary hypertension
Luke Howard, Imperial College London, UK

Oral Communications - Short talks

14:30 C001 Effect of a Cardiotoxic Pollutant-Phenanthrene on the Cardiac Function of Brown Trout (Salmo trutta)
Martins Ainerua, University of manchester, University of Benin, UK
14:45 C002 TREK1 regulates K+ efflux during LPS-induced inflammasome activation
Christopher Waters, University Of Kentucky, USA
15:00 C003 Anti-hypertensive properties and mechanisms of action of the extract and fractions from Persea americana Mill. leaf in rats
Joseph Badejo, University of Ibadan, Nigeria
15:15 C004 Inhibition of voltage-gated Na+ currents by eleclazine in adult rat atrial and ventricular myocytes
Andrew James, University of Bristol, UK
15:30 TBC
15:45 C006 Prediction of paroxysmal atrial fibrillation in the equine athlete using heart rate adjusted complexity analysis of normal sinus rhythm ECGs
Vadim Alexeenko, University of Surrey, University of Cambridge, UK
14:30 C019 Comparison of the effectiveness of lectures based on problems and traditional lectures in physiology teaching in Sudan
Nouralsalhin Alaagib, University of Khartoum, Sudan
14:45 C020 Digital resources and student attainment, using learning analytics to support student success
Louise Robson, University of Sheffield, UK
15:00 C021 Contesting TESTA: Time on assessed tasks is important for student learning
Nicholas Freestone, Kingston University, UK
15:15 C022 An Exploratory Study of Designing and Developing Core Physiology Curriculum for Pre-registration Nursing Education
Alison Wood, Edinburgh Napier University, UK
15:30 C023 Student perceptions of gamified learning activities
Douglas Bovell, Weill Cornell Medicine in Qatar, Qatar
15:45 C024 Impact of Year 1 Attendance on Exam Performance throughout Medical School
Christopher Torrens, University of Southampton, U
14:30 C091 Gαq-coupled Receptors Primarily Opts Direct Gαq Gating for Inhibiting TRPM8 Ion Channel
Xuming Zhang, Aston University, United Kingdom
14:45 C092 Modified hippocampal long-term potentiation in mdx mice can be recapitulated in wild type comparators by acute exposure to the pro-inflammatory cytokine, interleukin-6
Kimberley Stephenson, University College Cork, Cork, Ireland
15:00 C093 The parkinsonian neurotoxin MPTP induces cerebrovascular leakage that can be mitigated by photobiomodulation
Dan Johnstone, University of Sydney, Australia
15:15 C094 The effects of acute hypoxia on cognitive and cardiovascular parameters in healthy subjects
Rajeevlochan Ravi, University of Plymouth, United Kingdom
15:30 C095 Ion channels involved in pain pathways: An automated patch clamp study
Alison R. Obergrussberger, Nanion Technologies GmbH, Germany
15:45 C096 Estimation of synaptosome mitochondrial function in the TgF344-AD rat brain
Samuel D. Webb, Manchester Metropolitan University, United Kingdom

Poster Session A

Annual Public Lecture

PL02 Hunger Games - The Control of Appetite

Lora Heisler, University of Aberdeen, UK

Boyd Suite

Welcome Reception

Join us for a drink, and network with colleagues in an informal atmosphere with a traditional Scottish piper! Tickets are free but must be booked when you register.

Tuesday 9 July 2019

Registration

Joan Mott Prize Lecture

Mind the gap: connexins and cell communication in the kidney

Claire Hills, University of Lincoln, UK

Boyd Suite

Symposia

Organiser: Barry McDonnell, Cardiff Metropolitan University, UK
Co-organiser: John Cockcroft, Cardiff Metropolitan University, UK

For publication in Experimental Physiology.

10:00 SA021 Current state and outstanding mechanisms in normal arterial physiology – lessons from implantable cardiac devices
Eric Stöhr, Cardiff Metropolitan University, UK
10:30 SA022 Increased aortic stiffness in continuous-flow left ventricular assist device patients is associated with higher rates of adverse events
Hannah Rosenblum, Columbia University Irving Medical Center, USA
10:45 SA023 Right ventricular function in patients with pulmonary hypertension - The devil is in the details
Manreet Kanwar, Allegheny General Hospital, Pittsburgh, USA
11:00 SA024 Cardiovascular, cerebrovascular and exercise pressor reflexes in the bionic man
William Cornwell, University of Colorado Anschutz Medical Campus, USA

Organiser: Ruoli Chen, Keele University, UK
Co-organiser: Mark Dallas, University of Reading, UK

Summary:
Brain cells, in particular neurons, are vulnerable to a lack of oxygen. Neurons suffer extensive damage if oxygen supply is ceased leading to lasting brain damage. During oxygen deprivation, astrocytes support neuronal survival through metabolic stabilisation, and activate, which subsequently exert either neuroprotective or neurotoxic effects. Similarly, microglia activates with distinct patterns, which has implications in diverse CNS conditions, such as cerebral ischemia, Alzheimer’s disease. This symposium aims to discuss the response of neuron and glia cells to oxygen deprivation, and to explore to harness these responses for treatment of the brain diseases that are involved with oxygen deprivation.

10:00 The therapeutic potential of oxygen deprivation in neurological and vascular diseases
Arshad Majid, University of Sheffield, UK
10:30 SA028 Mechanisms of increased vulnerability to oxygen and glucose deprivation in astroglia carrying Alzheimer's disease mutations
Delores Martin-de-Saavedra, Northwestern University, USA
10:45 SA029 Ischaemic preconditioning of primary rat neural cultures induces tolerance to subsequent ischaemic insult (oxygen-glucose deprivation)
Ayesha Singh, Keele University, UK
11:00
Barry McColl, University of Edinburgh, UK

Organiser: Andreas Beyer, Medical College of Wisconsin, USA
Co-organiser: Petra Kleinbongard, University of Essen, Germany

Summary:
Little information exists on how the microvascular vascular endothelium contributes to development of chronic heart failure. Understanding the impact on microvascular function to development of heart failure is a critical step in defining disease progression and identify novel therapies. Increasing evidence, mostly indirect, connects microvascular defects to the development of heart failure, and, when counteracted, these microvascular defects can restore physiological cardiac function in animal models. This symposium will review latest findings how microvascular function contributes to development of heart failure in several clinical and per-clinical models and conditions.

Sponsored by the American Physiological Society. 

10:00 SA025 The coronary microcirculation in advancing age: does aging set up the development of heart failure
Amanda Jo LeBlanc, University of Louisville, USA
10:30 SA026 Is heart failure a coronary microvascular disorder?
Vahagn Ohanyan, Northeast Ohio Medical University, USA
10:45 Role of non-coding RNAs in development of heart failure
Christian Baer, University of Hannover, Germany
11:00 SA027 Coronary microcirculation in left and right heart failure
Daphne Merkus, University of Utrecht, Netherlands

Oral Communications - Short talks

10:00 C007 Increased cytoplasmic Ca2+ sensitivity of cardiac ryanodine receptors from the arrhythmic RyR2-P2328S mouse is independent of adrenergic challenge and FKBP12/12.6 regulation
Samantha Salvage, University of Cambridge, University of Cambridge, UK
10:15 C008 Cigarette Smoke Activates Calcium Influx in Human Airway Smooth Muscle Cells
Jinheng Lin, Newcastle University, UK
10:30 C009 Cystic fibrosis-transmembrane conductance regulator limits F-actin formation and promotes morphological alignment with flow in human lung microvascular endothelial cells
Adam Causer, University of Portsmouth, UK
10:45 C010 Carotid body chemosensitivity is enhanced during moderate exercise in human hypertension
Katrina Hope, University of Bristol, UK
11:00 C011 Orai3 expression increases during chemotherapy in lung adenocarcinoma and is involved in resistance to chemotherapy
Hiba AbouDaya, LPCM-EA46-67, Université Picardie Jules Vernes, France
11:15 C012 Adjustments in purinergic metabolism maintain the contribution of adenosine and ATP to carotid body chemosensory activity in ageing
Silvia V Conde, NOVA Medical School, Portugal
10:00 C043 GR activation stimulates NCC and determines diurnal rhythm of its phosphorylation
Jessica Ivy, University of Edinburgh, UK
10:15 C044 Ionic modulation of immune checkpoint proteins
Mia Shandell, University of York, UK
10:30 C045 Targeting proton secretion in CF airway epithelial cells to help restore airway pH homeostasis
Vinciane Saint-Criq, Newcastle University, UK
10:45 C046 Epithelial sodium channels containing the δ-subunit operate under high extracellular sodium concentrations
Sean Gettings, Newcastle University, University of Leuven, UK
11:00 C047 Localization of UT-B and AQP3 in developing bovine rumen epithelium
Chongliang Zhong, University College Dublin, Ireland
11:15 C048 Alterations in the colonic microbiome and age-dependent changes in stool water content, mucus production, mucosal inflammation and survival in Slc26a3 (DRA)-deficient mice and wt-littermates
Archana Kini, Hannover Medical School, Germany
10:00 C079 Altered inner-mitochondrial membrane dynamics disrupt skeletal muscle core-clock gene expression in type 2 diabetes
Brendan Gabriel, Karolinska Institutet, Sweden
10:15 C080 UK Effects of two-weeks of time restricted feeding on basal and postprandial metabolism in healthy men
Robert Jones, University of Nottingham
10:30 C081 Can acute exercise alleviate the impairment in glucose regulation after sleep restriction in healthy humans? A randomised crossover trial
Emma Sweeney, Northumbria University, UK
10:45 C082 HES1 expression is positively regulated by glycaemic challenges and exercise, and is perturbed in the skeletal muscle of type 2 diabetic individuals
Jonathon Smith, Karolinska Institutet, Sweden
11:00 C083 Targeted metabolomics in human skeletal muscle and plasma reveals distinct differences in key biomarkers of Type 2 diabetes
Pardeep Pabla, University of Nottingham, UK
11:15 C084 Endocrine regulation of fetal mitochondrial density in skeletal muscle and liver in fetal sheep
Katie Davies, University of Cambridge, UK

Refreshment break

Hodgkin-Huxley-Katz Prize Lecture

PL03 Allosteric modulation of glutamate receptors

Stephen Traynelis, Emory University, USA

Boyd Suite

Lunch and professional development sessions

Speaker panel:
Gordon Drummond, Edinburgh University, UK
Peter Cahusac, Alfaisal University, Riyadh, Saudi Arabia

Summary:
The session will explore different aspects of how statistics are used and abused. Patricia de Winter will focus on various ways of reporting risk and what the statistics actually mean in her talk title: “Figures often beguile me”, (Mis)reporting of Science and Health Statistics in the Media. This will be followed by Gordon Drummond giving practical advice about using statistical tests in his talk titled: What exactly can my test tell me – and do I need to test at all? Finally Peter Cahusac will briefly present an alternative way of looking at statistical evidence in: The Likelihood of Evidence-based Statistics.

Speaker panel:
Michael Wield, Stonewall Scotland

Summary:
This workshop presents an opportunity for Members to come together and discuss the inclusion of LGBT people within The Society. This interactive session will involve group work and will explore the experiences of LGBT people in the UK. We will examine the different ways The Society can ensure that LGBT people are included throughout the organisation.

Speaker panel:
Alex Dimov, BIOPAC Systems, Inc.
Steve Clifford, BIOPAC UK
Robert Jones, BIOPAC UK

Summary:
Life science educators aspire to deliver engaging lessons that enable students to obtain a high degree of knowledge while building a confident commitment to learning. This workshop will demonstrate the best way to set up your lab to improve student engagement while saving time. The workshop will include an overview of experiments, lesson workflow, lesson customization, live recordings of metabolic and biopotential data, and tips for an optimal experience for both students and educators.

Speaker panel:
Bella Williams, Head of Engagement, Understanding Animal Research

Summary:
The use of animals in research has long-been considered a difficult and controversial issue, where discussion with people outside a research setting can lead to challenging discussions, and even argument and conflict. Over the past 10 years this view of animal research in physiology has changed as the research sector has become increasingly open, with more information about research practices and husbandry available in the public domain. This session will look at how this change has come about, and what it means for the physiologist community; drawing on recent public opinion data and current communication practices in the academic and commercial sector.

The session will also explore some of the usual questions asked by lay people about using animals in research, providing tips, techniques and underlying principles for answering those questions authoritatively and openly.

Enter our Early Career Researcher kick-starter competition for a chance to win £1000 of funding for your research project!

We are pleased to announce that we will be running our kick-starter competition for Early Career Researchers for the second year running at Physiology 2019.  We welcome you to enter by visiting The Physiological Society Stand (#6) between 8th – 10th July to film a 30-60 second elevator pitch for your proposed project. All video entries will be reviewed, post-conference, by a panel of senior journal editors and a prize winner will be announced in the weeks following.

What is an elevator pitch?

Imagine you’re in a lift with the funder for research at your faculty. You have their undivided attention for 20 seconds – pitch your research idea for funding within that time, to see if you can convince them to help you kickstart your project.

What your pitch needs to cover…

What are you researching?
What are the challenges in your area of research?
What problem you are trying to solve?
Why is it important?
What will the funding enable you to do?

Terms and conditions apply, please see the Wiley staff on the day.

Finalists:

  • Zahra Alhumaidi
  • James Barber
  • Holly Bond
  • Edward Gray
  • Natasha Howley
  • Tamara McErlain
  • Cian O’Connor
  • Rebecca Robertson
  • Khalil Saadeh
  • Lucy Venables
  • Juliette Westbrook
  • Max Weston
  • Ella White
  • Sijia Yao
  • YiZhou Yu

Symposia

Organiser: Hugh Piggins, University of Bristol, UK

Summary:
Intrinsic 24h or circadian rhythms influence all aspects of our physiology and behavior. These rhythms allow our body to optimally align its key processes with the external cues of light and dark, temperature, food etc. Recurring night-shift work or exposure to light at night can result in misalignment of our circadian rhythms which increases risk of cancer, metabolic disorder, and cardiovascular disease. At one time circadian rhythms were believed to originate solely from the master brain clock in the hypothalamus, but we now know that molecular clock genes are rhythmically expressed in many peripheral tissues including lung, liver, and kidney. These clock genes are also expressed in the heart and since heart rate, stroke volume, and blood pressure vary over 24h, this raises the possibility that a local clock drives daily and circadian rhythms in cardiac function. However, it is unresolved as whether brain clock control of autonomic neurohormonal output or this putative intrinsic heart clock is the main driver of these rhythms in cardiac function. This symposium brings together researchers from around the globe to address the influence of metabolic cues, simulated jet-lag, autonomic tone, and a local circadian clock on cardiac function.

For publication in The Journal of Physiology.

14:30 SA033 Circadian rhythm in heart rate – role of intrinsic versus extrinsic factors
Mark Boyett, University of Manchester, UK
15:00 SA034 Direct recordings of cardiac sympathetic and vagal parasympathetic nerve activity to clarify the underlying mechanisms of circadian heart rhythm
Carol Bussey, University of Otago, New Zealand
15:15 SA035 Effect of disruption of the normal circadian rhythm on the heart
Yanwen Wang, University of Manchester, UK
15:30 SA036 Circadian rhythms in the heart
Martin Young, University of Alabama at Birmingham, USA

Organiser: James Garnett, Newcastle University, UK

Summary:
Homeostatic turnover and injury-induced repair of the lung epithelium requires precise control to maintain gas exchange function. Alveolar dysfunction is known to play a key role in the pathogenesis of a variety of degenerative, fibrotic, neoplastic and neonatal lung diseases. While an adult stem cell population is known to reside in the distal human lung which maintains alveolar epithelial function, and despite multiple studies aimed to characterize this cell type, many questions regarding the identity of epithelial stem cell niches in the human alveolus and its role in lung regeneration/repair still remain to be addressed. In this symposium, we will discuss recent advances as well as current limitations in our understanding of the origin, characteristics and function of alveolar epithelial stem cells.

14:30 SA037 Cell-cell interactions in normal human lung development
Emma Rawlins, Wellcome - MRC Cambridge Stem Cell Institute, UK
15:00 SA038 IPF-relevant cytokine cocktail induces a shift from alveolar to airway-like epithelial cells in an iPSC-derived model of alveolar epithelial progenitor differentiation
Eva Schruf, Boehringer Ingelheim, Germany
15:15 SA039 Unlimited expansion of putative distal lung bud tip progenitor cells from human pluripotent stem cells and their ex vivo and in vivo engraftment
Ya-Wen Chan, University of Southern California, USA
15:30 SA040 Macrophages and fibroblasts as niches in the adult lung
Jason Rock, Boston University School of Medicine, USA

Organiser: Michael Symonds, The University of Nottingham, UK

Summary: 
Since the rediscovery of brown fat in adult humans in 2009 there has been an exponential increase in research into this “new human organ” with high profile papers being published each month. It is therefore one of the most exciting and vibrant areas of bio-medical research worldwide and is multi-disciplinary. This has coincided with new insights in to our understanding of the development of brown adipocytes has led to the discovery that they share a common lineage with skeletal muscle. At the same time a plethora of new proteins have been discovered in brown fat that have the potential to promote whole body heat production. The precise role of brown fat to daily heat production in adults however remains a matter of intense debate with recent high profile papers suggesting that chronic cold exposure stimulates brown fat metabolism in vivo and in vitro. The symposium will therefore focus on the latest bio-medical and physiological related research into brown fat biology. This will include humans and the extent to which it can be a target tissue for promoting either heat production or glucose oxidation. It will also contrast this with the potential role of different anatomical locations of brown fat and compare both the development of these tissues and their response to chronic environmental challenges. Recent developments in stem cell biology and the ability to grow brown fat in vitro and/or induce its expression in vivo will also be covered. The symposium will uniquely offer an opportunity to debate the relationship between brown fat and energy balance and the extent to which they offer complementary strategies to improve metabolism, especially in overweight and obese adults. This topic always provides a vibrant and well attended symposium

For publication in Experimental Physiology.

14:30 Brown adipose tissue and heat production.
Barbara Cannon, Stockholm University, Sweden
15:00 SA030 Stem cell-based modelling of brown adipogenesis
Virginie Sottilie, University of Nottingham, UK
15:15 SA031 Elucidation of the roles of brown and BRITE fat genes
Mark Christian, Warwick University, UK
15:30 SA032 The gut hormone secretin triggers a gut-brown fat–brain-axis in the control of food intake
Martin Klingenspor, Technical University of Munich, Germany

Oral Communications - Short talks

14:30 C025 Transforming physiology tutorials for medical students through transdisciplinary collaboration with drama studies; taking the physiology tutorial case from the page to real life
Sean Roe, The Queen's University of Belfast, UK
14:45 C026 Image fraud and confidentiality as vehicles for learning about ethical issues in medical science teaching, a pilot study
Jenny Gregory, University of Aberdeen, UK
15:00 C027 Are Human Volunteer Practicals Essential for First Year Undergraduates Studying Human Physiology?
Elizabeth Sheader, University of Manchester, UK
15:15 C028 Increasing public engagement opportunities for final year physiology focused science communication projects
Michelle Keown, University of Manchester, UK
15:30 C029 Do pre-clinical medical students prefer summative or formative evaluations in physiology?
Mark Rae, University College Cork, Ireland
15:45 C030 A Video on the Pathophysiology of Heart Failure for Reinforcing First Year Medical Students' Learning: Do Video Techniques that Break from Medical Education Tradition Undermine the Video
Harry Witchel, Brighton and Sussex Medical School, UK
14:30 C055 Do the peripheral chemoreceptors contribute to exercise blood pressure in people with a family history of hypertension?
Audrey Smets, University of Bristol, UK
14:45 C056 Longer Home-based HIIT intervals elicit a greater improvement in aerobic capacity – a 6-week intervention study
Hannah Church, Liverpool John Moores University, UK
15:00 C057 Four-weeks, equipment-free, high-intensity interval training (HIIT) elicits improvements in the cardiorespiratory fitness and body composition of older adults irrespective of exercise supervision
Tanvir Sian, University of Nottingham, Royal Derby Hosital, UK
15:15 C058 During maximal exercise frontal lobe oxygenation decreases despite elevation in middle cerebral artery flow velocity
Stefanos Volianitis, Aalborg University, Denmark
15:30 C059 Exogenous testosterone therapy overcomes anabolic blunting to resistance-type exercise in older men
Nima Gharahdaghi, University of Nottingham, UK
15:45 C060 Carbohydrate ingestion is more beneficial for time trial performance in cycling than running
Alistair Black, Leeds Beckett University, UK
14:30 C097 Kv3.1 and Kv3.3 differentially contribute to action potential repolarization in principal neurons of the auditory brainstem
Nasreen Choudhury, University of Leicester, UK
15:00 C099 Presynaptic modulation of synaptic release and plasticity via NMDA receptor activation at the dorsal cochlear nucleus multisensory synapses
Masa Svent, University of Leicester, UK
15:15 C100 The effects of daily transcutaneous vagus nerve stimulation on autonomic tone
Beatrice Bretherton, University of Leeds, Leeds Teaching Hospitals NHS Trust, UK
15:30 C101 Amyloid-β inhibits mitochondrial large-conductance calcium-activated potassium channel
Yevheniia Kravenska, Nencki Institute of Experimental Biology of the Polish Academy of Sciences, Bogomoletz Institute of Physiology of the National Academy of Sciences of Ukraine, Poland
15:45 C102 Mapping atrial receptor distribution in the right atrial subendocardial neural plexus of the rat
Thomas Campbell, University College Dublin, Ireland
14:30 C115 The H2S-releasing NSAID, ATB-346, significantly attenuates human myometrial contraction
Sarah Arrowsmith, University of Liverpool, UK
14:45 C116 Adaptive remodeling recovers impaired skeletal muscle function and microvascular perfusion after compensatory hypertrophy of the rat heart
Peter Tickle, University of Leeds, UK
15:00 C117 Increased β-amyloid production is associated with diabetes-induced vascular dysfunction
Paul Meakin, University of Leeds, UK
15:15 C118 Phosphodiesterase 1: A Novel Drug Target for Pulmonary Arterial Hypertension
Zaher Al Bakour, University of Aberdeen, UK
15:30 C119 Soluble fms-like Tyrosine Kinase 1 (sFlt1) is Downregulated in Aortic Valve Stenosis, Promoting Intravalvular Neovascularisation
Christopher Lewis, University of Aberdeen, UK
15:45 C120 Sex differences in basal cerebral perfusion: contribution of nitric oxide
Aaron Ward, University of Wisconsin-Madison, USA

Poster Session B

Annual Review Prize Lecture

PL04 Circuits Solutions for Programming Actions

Silvia Arber, University of Basel, Switzerland

Boyd Suite

Society Dinner

Every year the Society Dinner is the foremost social activity and Physiology 2019 is no different. Your ticket includes a welcome drink, three course meal, and wine and soft drinks, and ceilidh on the ballroom’s sprung dance floor.
Venue: Beach Ballroom, Beach Promenade, Aberdeen AB24 5NR
Cost: £60.00, and can be booked during registration.

Wednesday 10 July 2019

Registration

Symposia

Organiser: Katharine Dibb, University of Manchester, UK
Co-organiser: Jessica Caldwell, University of Manchester, UK

Summary:
Normal cardiac contraction requires a synchronous rise of systolic calcium. This is brought about by the close association of calcium channels on transverse (t)-tubules and RyR release channels on the intracellular calcium store which form dyads.  Alteration of these structures in disease contributes to cardiac dysfunction. Advanced imaging technologies are beginning to characterise these structural changes at the molecular level and link them to changes in function. Current work addressing how this remodelling translates to disturbed calcium handling, how t-tubules are built and if structural recovery of t-tubules may provide a therapeutic approach will form the basis for this symposium.

09:00 SA047 cBIN1: from t-tubule folds to dyad organization, microparticles and clinical utility
TingTing Hong, Cedars-Sinai Medical Center, USA
09:30 SA048 Disordered yet functional atrial t-tubules following recovery from heart failure
Jessica Caldwell, University of Manchester, UK
09:45 SA049 Microdomain signaling around ryanodine receptors in cardiac disease
Eef Dries, KU Leuven, Belgium
10:00 SA050 Understanding dyadic plasticity in cardiomyocytes
William Louch, University of Oslo, Norway

Organiser: Lee Romer, Brunel University London, UK

Summary:
The aim of this symposium is to discuss the respiratory influences on oxygen transport and how they might exacerbate exercise-induced respiratory and/or peripheral muscle fatigue and compromise endurance performance.  Specifically, the two featured presentations will highlight the role of neural feedback from working limb and respiratory muscles in limiting exercise tolerance in health and the effect of unloading the respiratory muscles on central and peripheral blood flow regulation in chronic disease.

09:00 SA043 Blood flow distribution between respiratory vs. locomotor muscles during exercise
Bill Sheel, University of British Columbia, Canada
09:30 SA044 Pulmonary vascular dysfunction and exercise intolerance in heart failure
Bryan Taylor, University of Leeds, UK
09:45 SA045 Respiratory influences on oxygen transport and exercise performance – a cystic fibrosis perspective
Zoe Saynor, University of Portsmouth, UK
10:00 SA046 The effect of manipulating respiratory muscle loading on respiratory and locomotor muscle blood flow regulation during exercise in health and chronic disease
Ioannis Vogiatzis, Northumbria University, UK

Organiser: Nimesh Mody, University of Aberdeen, UK
Co-organiser: Justin Rochford, University of Aberdeen, UK

Summary:
Transcriptional regulation by nuclear receptors is a fundamental way to regulate metabolic pathways in response to changes in nutrition and physiological states. The regulation of these signalling pathways is impaired in metabolic diseases like obesity and type-2 diabetes and thus nuclear receptors are the target of drugs to treat these diseases in humans. The investigators in this symposium have all been at the fore-front of research into the action of nuclear receptor and begun to examine some of the complexity of transcriptional programmes in terms of chromatin remodelling, alterations in transcription factor binding, cooperation and cross-talk of pathways.

09:00 Nuclear receptors and transcriptional regulation in metabolism and endocrinology
Adriana Maggi, University of Milan, Italy
09:30 LXRα phosphorylation in metabolic diseases: Non-alcoholic fatty liver and cardiovascular disease
Ines Pineda-Torra, University College London, UK
09:45 SA041 Regulation of the hepatic feeding response by combined action of insulin and glucocorticoid receptor signalling
Lars Grøntved, University of Southern Denmark, Denmark
10:00 SA042 Regulation of lipid metabolism by the nuclear receptor PPARα
Sander Kersten, Wageningen University & Research, The Netherlands

Oral Communications - Short talks

09:00 C049 Neutraceutical targeting of the bile acid receptor, farnesoid X receptor, for intestinal disease
Ciara Fallon, The Royal College of Surgeons in Ireland, Ireland
09:15 C050 Differential effects of ceramide on permeability in human airway epithelial cells
Kameljit Kalsi, St George's University of London, UK
09:30 C040 Regulation of the cystic fibrosis transmembrane conductance regulator (CFTR) by the nuclear bile acid receptor, farnesoid X receptor
Jessica Smyth, Royal College of Surgeons in Ireland, Irelandv
09:45 C052 Pancreatic stellate cells serve as a brake mechanism on pancreatic acinar cell calcium signaling modulated by methionine sulfoxide reductase
Zong Jie Cui, Beijing Normal University, China expression
10:00 C053 Modulation of ion transport and pro-inflammatory cytokine release by HO-1/CO in cultured human airway epithelial cells
Wing Hung Ko, The Chinese University of Hong Kong, Hong Kong
10:15 C054 Artificial sweeteners increase the pathogenic potential of model gut bacteria on the intestinal epithelium
Aparna Shil, Anglia Ruskin University, UK
09:00 C031 A proposal concerning what to do about p values
David Colquhoun, Univrsity College London, UK
09:15 C032 Development of flexible experiential learning exercises to deliver online practical teaching
Steve Tucker, University of Aberdeen, UK
09:30 C033 Physiology for all: Increasing undergraduate student choice increases engagement with physiology
Sarah Hall, Cardiff University, UK
09:45 C034 Are learning technologies a barrier to education? – The results of a survey investigating engagement with an online development portfolio for bioscience students
Matthew Hardy, University of Bradford, UK
10:00 C035 Student-created video resources can enhance medical science practical class assessment
Cameron Malcolm, University of Aberdeen, UK
10:15 C036 Data capture, analysis and assessment in physiology education
James Clark, King's College London, UK
09:00 C103 ASICs in mechanosensation: ASIC1b deletion in mice reduces blood pressure, perturbs fine motor control in vivo, and reverses amiloride sensitivity of muscle spindle afferent firing
Guy Bewick, University of Aberdeen, UK
09:15 C104 Modelling Temperature Sensing by Parvocellular Neurones of the Paraventricular Nucleus of the Hypothalamus
Fiona O'Brien, University of Liverpool, UK
09:30 C105 The paralaminar nucleus of the amygdala: a potential nexus in the regulation of stress in major depressive disorder
Liadan Tobin-Schnittger, University College Dublin, Trinity College Dublin, UK
09:45 C106 Maternal obesity alters intermediate memory and anxiety-related behaviours in adult mouse offspring
Emily Mort, University of Cambridge, UK
10:00 C107 Effect of spinal cord stimulation on autonomic function in patients with failed back surgery syndrome
Sheila Black, Leeds Teaching Hospitals NHS Trust, University of Leeds, UK
10:15 C108 Effects of indirect cocaine exposure and early postnatal fostering on epigenetic DNA modification and behavioral phenotypes of drug naïve mice
William Daniels, University of Witwatersrand, South Africa
09:00 C121 The muscarinic cation current in murine ileal myocytes (mICAT) inhibited by ketamine can be recovered by TRPC4 agonist (-)-englerin A
Alexander Zholos, ESC “Institute of Biology and Medicine”,
09:15 PC245 Trimethylamine, a gut bacteria metabolite, increases in rat plasma with age and affects vascular smooth muscle cells viability
Marcin Ufnal, Medical University of Warsaw, Poland
09:30 C123 Junctophilin-2 is Necessary for the Formation of Peripheral Ca2+ Signalling Domains in Contractile Vascular Smooth Muscle Cells
Harry Pritchard, University of Manchester, UK
09:45 PC262 Ultrasound and Microbubble Gene Delivery for Targeting Altered Placental MicroRNAs in Preeclampsia
Sonya Frazier, University of Glasgow, UK
10:00 C125 Restricted Dietary Intake of Zinc Modulates Parameters of Haemostasis
Um-May Sumya, University of Aberdeen, UK
10:15 C126 The antiepileptic agents phenytoin and valproate inhibits oxytocin-induced contractions of myometrium isolated from absence epileptic WAG/Rij rats
Aysegul Kurt, Karadeniz Technical University Faculty of Medicine, Turkey

Refreshment break

Sharpey Schafer Prize Lecture

PL05 From Retroviruses to Human Birth

Roger Smith, The University of Newcastle, Australia

Boyd Suite

Lunch

Enter our Early Career Researcher kick-starter competition for a chance to win £1000 of funding for your research project!

We are pleased to announce that we will be running our kick-starter competition for Early Career Researchers for the second year running at Physiology 2019.  We welcome you to enter by visiting The Physiological Society Stand (#6) between 8th – 10th July to film a 30-60 second elevator pitch for your proposed project. All video entries will be reviewed, post-conference, by a panel of senior journal editors and a prize winner will be announced in the weeks following.

What is an elevator pitch?

Imagine you’re in a lift with the funder for research at your faculty. You have their undivided attention for 20 seconds – pitch your research idea for funding within that time, to see if you can convince them to help you kickstart your project.

What your pitch needs to cover…

What are you researching?
What are the challenges in your area of research?
What problem you are trying to solve?
Why is it important?
What will the funding enable you to do?

Terms and conditions apply, please see the Wiley staff on the day.

Symposia

Organiser: Ursula Seidler, Hannover Medical School, Germany
Co-organiser: Vinciane Saint-Criq, Newcastle University, UK

Summary:
Epithelial anion transport maintains the fluidity in glandular outflows, establishes pH microclimates, regulates mucus secretion, and protects mucosal surfaces from noxious agents and bacterial pathogens. The importance of Cl- and HCO3- secretion and its derangements in congenital and acquired diarrheal diseases, cystic fibrosis, peptic diseases, inflammatory bowel disease had been realized many decades ago, more recently pancreatitis, asthma, cancer and other diseases were added to the list. Despite the obvious importance of anion transport processes in health and disease, it proved difficult to understand the molecular details and to find appropriate treatment. The inability to culture differentiated intestinal cells, the inaccessibility of epithelia in the native state, the difficulty to patch brush border membranes, and of measuring anion fluxes have all hindered rapid progress. Nevertheless, in the last few years a number of long-struggled-for milestones have been reached, and unexpected and astonishing findings have been made. This symposium aims to highlight recent groundbreaking discoveries in the field of epithelial anion transport.

13.30 SA051 Molecular basis for dynamic change in the bicarbonate permeability of anion channels
Min-Goo Lee, Yonsei University, Seoul, Korea
14.00 SA052 Anion channels of the Anoctamin/TMEM16 family as modulators of Ca2+ signalling and mucin secretion
Roberta Benedetto, University of Regensburg, Germany
14.15 SA053 The Volume Regulated Anion Channel: from molecular identification to physiological roles and 3D structure
Sara Bertelli, Istituto di Biofisica, CNR, Italy
14.30 SA054 The consequences of altered wnt signaling in the cystic fibrosis intestine
Lane Clarke, University of Missouri, USA

Organiser: Guy Bewick, University of Aberdeen, UK

Summary:
Mechanosensation has been the least understood of all the senses, with even the first step of stimulus detection under dispute. However, recent discoveries are radically revising the classical model of mechansensory physiology. They also promise new principles relevant throughout sensory physiology, from motor control, posture and athletic performance, through touch, spasticity, hearing and balance to blood pressure regulation, vision and musculoskeletal development and repair. As the largest mechanosensory organs in the body, the size and accessibility of muscle spindles was a great attraction for early studies of mechanosensation. Now these same advantages are offering exciting opportunities and insights for the next generation of researchers studying primary mechanosensory terminals.

Partly supported by an unrestricted educational grant by Nanion and bio-techne.

13:30 SA055 Chemotherapy-induced pathophysiology of muscle spindles in rats
Timothy Cope, Georgia Tech, USA
14:00 Piezo2 is essential for the maintenance of skeletal integrity by acting as a key regulator of the proprioceptive system
Eran Assaraf, Weizmann Institute, Israel
14:15 SA056 Altered muscle spindle function in mouse models of muscular dystrophy
Bridgette Watkins, LMU Munich, Germany
14:30 SA057 Diet induced obesity alters muscle spindle afferent mechanosensation and Hoffmann’s Reflex excitability in adult mice of both sexes
Katherine Willkinson, San Jose State University, USA

Organiser: Geraldine Clough, University of Southampton, UK
Co-Organiser: Jefferson C Frisbee, Western University, Canada

Summary:
Societies around the world are increasingly struggling with the social and economic challenges of cardiovascular disease (CVD) and CVD risk.  However, traditional markers of vascular dysfunction have poor predictive power for understanding and predicting more complex functional/clinical outcomes. This symposium will present innovative investigative and conceptual approaches to the multi-scale nature of vascular and microvascular dysfunction and explore whether we may  gain useful insight into system behaviour and organ perfusion in health and disease/disease risk.

For publication in Experimental Physiology.

13.30 SA058 Shifted vascular optimization: The emergence of a new arteriolar behaviour with chronic metabolic disease
Jefferson C Frisbee, Western University, Canada
14.00 SA059 Perivascular adipose tissue – an immune cell metropolis
Sarah B Withers, University of Salford, UK
14.15 SA060 Extracting new information from old waveforms: Attractor reconstruction where maths meets medicine
Manasi Nandi, King’s College London, UK
14.30 SA061 Multi-scale, multi-domain analysis of microvascular flow dynamics.
Andrew J Chipperfield, University of Southampton, UK

Oral Communications - Short talks

13:30 C013 Ca2+/Calmodulin-Dependent Protein Kinase II Activation Promotes Ryanodine Receptor Dispersion and Dysfunction During Heart Failure
Terje Kolstad, University of Oslo, K.G. Jebsen Center for Cardiac Research, Norway
13:45 C014 Dual antiarrhythmic properties of phosphodiesterase-5 inhibitors suppress Ca2+ waves in systolic heart failure
David Hutchings, University of Manchester, UK
14:00 C015 Adult mitochondria show sexual dimorphism after prenatal hypoxia
Kim Hellgren, University of Manchester, UK
14:15 C016 Substrate affects contractile behaviour of hiPSC derived cardiomyocytes
Eline Huethorst, University of Glasgow, University of Glasgow, UK
14:30 C017 Do repolarisation abnormalities disrupt calcium handling and contribute to impaired diastolic function in heart failure?
Grace Anderson, King's College London, UK
14:45 C018 Antiarrhythmic effects of glucagon-like peptide-
Svetlana Mastitskaya, University College London, UK
13:30 C067 Human disuse atrophy may be wholly explained by sustained declines in muscle protein synthesis in the absence of increased muscle protein
Matthew Brook, University of Nottingham, UK breakdown
13:45 C068 Compromised skeletal muscle stem cell function in a mouse model of hyperlipidaemia and atherosclerosis
Joseph Barlow, Hull York Medical School, UK
14:00 C069 Transcriptional pathways of skeletal muscle protein synthesis and turnover are associated with the post-exercise protein and polyphenol supplementation mediated recovery from maximal eccentric contractions
George Pavis, University of Exeter, UK
14:15 C070 Post-Exercise and Pre-Sleep Protein-Polyphenol Supplementation Attenuates NF-kB Related Signalling and Improves Recovery following Muscle-Damaging Eccentric Exercise
Tom Jameson, University of Exeter, UK
14:30 C071 The effect of sprint interval training in fasted and carbohydrate-fed states on exercise performance including inter-individual adaptive responses in recreationally active males
Brian Carson, University of Limerick, University of Limerick, Ireland
14:45 C072 Gravitational transitions induce systemic oxidative-nitrosative stress and cerebral hyperperfusion in humans
Damian Bailey, University of South Wales, UK
13:30 C085 A novel protein regulator of adipogenesis
Pola Verschoor, University of Aberdeen, UK
13:45 C086 Leptin differentially remodels vertebrae and tibia trabecular bone independent of load in vivo
Nicola Aberdein, Sheffield Hallam University, UK
14:00 C087 Effect of maternal resveratrol administration on offspring sugar preference and glucose tolerance in a rat model of obese pregnancy
Nozomi Itani, King's College London, UK
14:15 C088 5β-reductase (AKR1D1) deletion drives hepatic inflammation, fibrosis and tumour development in vitro and in vivo
Shelley Harris, University of Oxford, UK
14:30 C089 Carotid sinus nerve denervation improves hepatic function in young and old animals with metabolic dysfunctions exacerabted by long-term hypercaloric diet consumption
Cláudia Batista, NOVA Medical School | Faculdade Ciências Médicas, Universidade Nova de Lisboa, Portugal
14:45 C090 Grazing induces phasic preference for high-fat diet in male rats
Janine Dovey, Cardiff University, UK

End of conference

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Satellite Symposia

The Annual Conference is our flagship event and we want to continue to develop this so that it is more international in scope, provides a platform for dissemination of high quality research and appeals to the broadest physiology community. In addition, one of our key strategic objectives is to increase involvement of subdisciplines of physiology that are not well represented at our meetings.

With this in mind, we are hosting a number of stimulating satellite symposia to complement Physiology 2019 on Sunday, 7 July.

Cellular mechanisms of anti-cancer induced cardiotoxicity
Organiser: Susan Currie, University of Strathclyde, UK
Co-organiser: Margaret Cunningham, University of Strathclyde, UK

Fatigue as a limitation to performance
Organiser: Derek Ball, University of Aberdeen, UK
Co-organiser: Ron Maughan, University of St Andrews, UK

Physiology of obesity and diabetes
Organiser: Lora Heisler, University of Aberdeen, UK
Co-organisers: Peter Aldiss, University of Birmingham, UK
Daniel Brayson, University College London, UK
Jo Lewis, University of Cambridge, UK

Renal physiology: Recent advances and emerging concepts
Organiser:  Morag K Mansley, The University of Edinburgh, UK
Co-organiser:  Robert W. Hunter, The University of Edinburgh, UK

The placenta and maternal metabolic regulation in health and disease
Organisers: Luis Sobrevia, Universidad Católica de Chile, Chile
Raheela Khan, University of Nottingham, UK
Abigail Fowden, University of Cambridge, UK

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Registration

Online registration is closed.

Onsite registration will open at 07:30 on Monday, 8 July at the West Entrance of The Aberdeen Exhibition and Conference Centre.

If you need any assistance, please email meetings@physoc.org or call +44 (0)20 7269 5710 and ask to speak to the events team.

Registration rates

CategoryEarly (until 31 May 2019)Late (from 1 June 2019)Day fee*
Full Member£150£250£125
Affiliate Member£90£140£70
Honorary or Retired MemberFreeFreeFree
Undergraduate MemberFreeFreeFree
Non-Member£250£350£175
Non-Member ECR*£130£180£90

Registration fees include all refreshments, including tea and coffee, lunch and drinks during the welcome reception.

Children under 18 can attend Physiology 2019 free of charge. If you are intending to bring your child(ren), then please do let us know by emailing meetings@physoc.org 

* Non-Member ECR is a non-Member of The Society who is enrolled in post-graduate studies (PhD or MSc) or is in a junior post-doc position.

** If you want to register for the day only, please email meetings@physoc.org or call +44 (0)20 7269 5710 and ask to speak to the events team.

Optional extras

Free walking tour

Explore the city with our free walking tour of Aberdeen.

Date: Sunday, 7 July 2019.
Time: 16:00 – 17:45
Cost: FREE, but you must pre-register as places are limited. To register, please email meetings@physoc.org

Welcome Reception

The Welcome Reception will also officially open the conference. Join us for a drink, and network with colleagues in an informal atmosphere with a traditional Scottish piper! Tickets must be booked when you register.

Date: Monday, 8 July
Time: 19:00- 20:00
Venue: Aberdeen Exhibition and Conference Centre
Cost: FREE, but you must pre-register

Society Dinner and Ceilidh

Every year the Society Dinner is the foremost social activity and Physiology 2019 is no different. Your ticket includes a welcome drink, three course meal, and wine and soft drinks, and ceilidh on the ballroom’s sprung dance floor.

Date: Tuesday, 9 July
Time: 19:30 – late
Venue: Beach Ballroom, Beach Promenade, Aberdeen AB24 5NR
Cost: £60.00, and can be booked during registration.

Applying for a visa

  • Do you need a visa to be able to participate in the meeting?

    To check whether you need a visa to be able to attend, please click here.

    For more detailed information, application forms and guidance notes, please visit the official UK visa website.

    It is recommended that you apply for your visa well in advance (at least 12 weeks before the meeting) as applications for UK visas in certain countries can take longer than expected. Attendees are requested that they book early enough and apply for a visa with sufficient time prior to the conference. The conference organisers cannot be held responsible if delegates do not receive their visas in time, and the cancellation policy will automatically apply. Every effort will be made to support genuine applications.

    The conference organisers are happy to provide you with documentation to support your application which will be sent as a PDF attachment. If you require a hard copy to be sent to you, please include your mailing (postal) address. The Physiological Society will only send via regular post.

    Documentation to support visa applications will only be provided to those attendees who have submitted an abstract which has been accepted for presentation at the conference, registered and paid to attend.

    Please complete the webform below, and attach confirmation of your registration, and submitted abstract.

    Please note that The Society can not influence consular decisions, letters will be distributed within 10 working days - it is the responsibility of the attendee to allow sufficient time for processing.


  • Date Format: DD slash MM slash YYYY




















  • Date Format: DD slash MM slash YYYY

  • Your data will be processed in accordance with our Fair Processing Notice.


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Key information

Registration

The conference is being held at the Aberdeen Exhibition and Conference Centre (AECC), Bridge of Don, Aberdeen, AB23 8BL, UK.

When you arrive, please register and collect your badge, conference pack and programme book from the registration desk in the foyer of the West Entrance of the AECC.

The registration desk will be open on the ground floor at the following times:

Monday, 8 July – 07:00 – 19:30
Tuesday, 9 July – 07:00 – 18:30
Wednesday, 10 July – 08:00 – 15:00

For security reasons, please wear your badge at all times during the conference.

Plan your itinerary

Create your own personal itinerary for Physiology 2019 using the itinerary planner powered by Scholar One.

You can select the sessions that you want to attend, and even download these to your calendar, including full abstract details.

The mobile app is called “MyItinerary by ScholarOne” and is available to download from the iOS and Android marketplaces.

Refreshments

Your registration fee includes the following refreshments:

  • Water, available from water-coolers, at all times in the Main Arena
  • Tea and coffee in the Main Arena from 07:30–08:30 and 11:30–12:00 each day
  • Sandwich lunch available each day from 13:00–14:00 (except on Wednesday when it is 12:00–13:00)
  • Tea, coffee and soft drinks during poster sessions
  • Alcoholic and soft drinks during the welcome reception

Travelling to/from the AECC

AECC sits right next to the A90. It’s only a 15-minute taxi ride from Aberdeen railway and bus stations in the city centre.

Coach schedule

Monday 8 July

07:00–09:00 Shuttle from the DoubleTree by Hilton Aberdeen City Centre to AECC. Please be at the DoubleTree by Hilton at 08:30 latest. 

19:00–21:30 Shuttle from AECC to the DoubleTree by Hilton Aberdeen City Centre

Tuesday 9 July

07:00–09:00 Shuttle from the DoubleTree by Hilton Aberdeen City Centre to AECC

18:00–20:00 Shuttle from the AECC to DoubleTree by Hilton Aberdeen City Centre

19:00 For the conference dinner – Collect from AECC to the Beach Ballroom

22:30 Collect from Beach Ballroom to Schoolhill and Holiday Inn Express Aberdeen – Bridge of Don

23:00 Collect from Beach Ballroom to Schoolhill and Holiday Inn Express Aberdeen – Bridge of Don

Wednesday 10 July

07:00–09:00 Shuttle from the DoubleTree by Hilton Aberdeen City Centre to AECC

13:30–16:00 Shuttle from AECC to the DoubleTree by Hilton Aberdeen City Centre

Alternative transport

By bus

  • First Bus services – 1 and 2, Park and Ride X40 (contactless payment can be used on all First Bus services)
  • Stagecoach services – 62, 63, 67, 68, 250 (cash only – Zone 1 Dayrider costs £3.80)

By taxi

  • Aberdeen Taxis: 01224 200200
  • Comcabs: 01224 353535
  • Rainbow: 01224 878787

From Aberdeen airport to Aberdeen city centre

Stagecoach 727 – this runs every 20 minutes and costs £3.50. You can get off at either Union Street or Union Square.

Join the conversation

Please use the official hashtag #Physiology2019 for your Tweets and Instagram posts.

Venue Accessibility

Aberdeen Exhibition and Conference Centre

Where possible, efforts have been made at Aberdeen Exhibition and Conference Centre to ensure that physically challenged persons and wheelchair users have full access to the venue. The venue boasts the following features:

Entrance

  • Automatic doors at the entrance with a low-level push pad suitable for wheelchair users
  • The Arena has wide main entry doors, with stewards on hand to open

Parking

  • There are designated spaces for blue badge holders, nearest to the venue

Lifts

  • All halls in the main building are at ground level. There are several lifts throughout AECC to the upper levels. These can be found at Concourse level (leading to floors 1-3), at Crombie/Boyd Orr (leading to the Gordon Room), and at Room 23. Wheelchair lifts are available also at the Fleming Auditorium.

Induction loops

  • There is a permanent induction loop for the hard of hearing in the Forbes Suite; portable induction loops are available for some other areas. The Main Reception Conference Entrance also has a permanent induction loop system.

Please note, the Venue requires 48 hours notice to install the portable hearing loop. Please email The Physiological Society Events Team on events@physoc.org  or call to request an induction loop.

Toilets

  • AECC provides wheelchair accessible and disabled toilets throughout the venue

Beach Ballroom (Society Dinner)

The Society Dinner and Ceilidh will be held at the Beach Ballroom. The venue has the following features:

Access

  • The Beach Road entrance gives access to the ground floor where the Society Dinner and Ceilidh will take place
  • There is a moderately-sloped ramp (width 185cm) that leads from the carpark into the Beach Ballroom for wheelchair users
  • Internally, all areas of the Beach Ballroom are accessible for wheelchair users (either level flooring or via a ramp)

Parking

  • There are two designated disabled parking bays within the carpark
  • The dimensions of the disabled parking bays are 11ft x 16ft

Toilets

  • There is an accessible toilet located adjacent to the car park entrance
  • The dimensions of the accessible toilet are 4ft 6in x 7ft 7in

Additional Info

  • A bowl of water can be provided for an assistance dog

Mercure Ardoe House Hotel

The Satellite Meeting ‘Physiology of Obesity and Diabetes’ will be held at the Mercure Ardoe House Hotel.  The Ardoe House Hotel is accessible in the following ways:

Access

  • Ardoe House Hotel and Spa is fully accessible via portable ramps and lifts, with exception to bedrooms in the ‘old house’ part of the hotel
  • The stairs within the hotel all have handrails
  • Entrance to the hotel usually requires use of a ramp so assistance may be required by wheelchair users
  • Guests should contact staff if in need of a portable ramp

Parking

  • The Mercure Ardoe House Hotel has its own car park without a height restriction barrier
  • There are two blue badge parking spaces in the front carpark and six in the rear carpark of the hotel, all with dimensions 13ft 1in x 16ft 5in

Lifts

  • There is a standard lift at the hotel for public use
  • The dimensions of the lift are 3ft 1in x 4ft 4in
  • The lift has a mirror to aid reversing

Toilets

  • Accessible toilets are available at the Ardoe Hotel
  • The dimensions of the accessible toilets are 5ft x 5ft 7in

Additional Information

  • Staff at the Ardoe House Hotel receive disability awareness/equality training
  • There are three bedrooms with accessible ensuite facilities
  • Documents at the hotel can be requested in braille and in large print
  • Water can be requested for assistance dogs
  • Motorised scooters are allowed in public parts of the hotel

About Aberdeen

The city of Aberdeen and the surrounding area along the north-east coast of Scotland, UK form the county of Aberdeenshire.

Filled with stretching beaches and sheer cliffs, Aberdeenshire has some of the UK’s most breath-taking scenery. The city itself also has lots to offer including a warm Scottish welcome and customs: Ceilidh, whisky, haggis, and dophin and seal watching from the city’s two rivers.

As the ‘Oil Capital of Europe’, we have excellent transport links, including a well-served international airport, plus restaurants for every budget and taste.

For the more adventurous, there are Olympic standard indoor sport and aquatic facilities, the UK’s largest mountain range (Cairngorm National Park), and Royal Deeside, where the royal family spend the summer and attend local Highland Games.

Completing the list are more than 300 castles and stately homes, including Balmoral and dramatic Dunnotar (setting for Mel Gibson’s Hamlet), numerous ‘recumbent’ stone circles, Neolithic hillforts, decorated Pictish standing stones and 20hr/day of natural light to fit it all in. There is something for everyone – including, of course, the unmissable ceilidh dance to burn off those calories from The Physiological Society dinner.

Aberdeen is associated with five Nobel Prizes, including John Macleod’s for Medicine or Physiology for studying insulin. It has two Universities, the University of Aberdeen and Robert Gordon University, and is Scotland’s ‘Safest University City’. The University of Aberdeen (est. 1496) runs a very popular Physiology degree, annually awarding a Society-sponsored Physiology Prize.

Local Organising Committee

Derek Ball, University of Aberdeen, UK
Guy Bewick, University of Aberdeen, UK
Katherine Burgess, Robert Gordon University, UK
Stephen Davies, University of Aberdeen, UK
Mirela Delibegovic, University of Aberdeen, UK
Gordon McEwan, University of Aberdeen, UK
Graeme Nixon, University of Aberdeen, UK
Nimesh Mody, University of Aberdeen, UK
Ann Rajnicek, University of Aberdeen, UK
Iain Rowe, Robert Gordon University, UK
Derek Scott, University of Aberdeen, UK
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Travel Grants

As part of our aim to ensure physiology is flourishing we provide travel grants to enable physiologists to network and attend conferences. In a rolling, 12-month period the following funding is available: £700 for Members, £500 for Affiliate Members and £100 for Undergraduate Members.

Where The Society’s main meetings fall less than 12 months apart, Members applying for travel grants to attend sequential meetings WILL BE ELIGIBLE to apply for funding.

The deadline for applying to travel funding for Physiology 2019 is 31 May 2019.

Apply here

Funding for Carers

In order to ensure our activities are inclusive, we have established a Carer’s Fund to support members with caring responsibilities, as well as those that need carers.  The grants are intended to go towards the cost of the attendee’s care arrangements for any meeting or workshop that we organise. More information about eligibility and scheme criteria can be found here.

Apply here

Childcare

Children under 18 can attend Physiology 2019 free of charge.

Children over 10 years of age can sit with their parents and/or carers and read, or use a tablet on silent, in sessions. Please do let us know by emailing meetings@physoc.org so we can register them.

If you are intending to bring children under 10 years of age, then please do let us know by emailing meetings@physoc.org as we will provide a childcare facility if there is demand.

No food will be provided, but water will be freely available.

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Exhibition and sponsorship

Physiology 2019 is the annual conference of The Physiological Society and as such, a major event in the physiological community’s calendar. Anticipated attendance is expected to be at around 1000 delegates, all active in physiological research.

An extensive range of sponsorship packages to suit every budget offers prime opportunities to promote your organisation at Physiology 2019, and to create invaluable contacts amongst physiologists from the UK, Europe and worldwide. The trade exhibition is a high-profile platform that will showcase products, technology and services.

Demand is expected to be high so booking early is advisable.

To register your interest, please email Uta Boeger Brown physocexhibition@biomedex.co.uk

Exhibition hall floorplans >>> 
Opportunities brochure >>>
Booking form >>>

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