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  • Autumn 2005 - Issue Number 60
  • Autumn 2005 - Issue Number 60

Below are the feature articles from Physiology News Issue 60, Autumn 2005.

To read the full articles please download the issue.

Spontaneous transient currents, long slow oscillations… or just wobbles?

Len Best offers a cautionary tale of the elusive nature of an electrophysiological phenomenon
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A new experimental platform for plasticity
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How to perform well in the heat
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Different polyamine concentrations underlie the regional difference in the strong inward rectifier K+ current in the heart

The inward rectification of a K+ current in the cardiac atrial myocytes is stronger than that in the ventricular myocytes. This new study reveals that different intracellular polyamine concentrations underlie the difference

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Control of oxygen delivery within skeletal muscle

The delivery of O2 to contracting myocytes ultimately limits the scope of oxidative metabolism and is also an important determinant of substrate selection. New data provide insight into the matching of O2 supply and demand in muscles of differing fibre type
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How do receptor-associated proteins regulate the turnover of receptors at a synapse?
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The emerging role of calcium-dependent exocytosis in ATP release from nonexcitable cells

The recent demonstration that intracellular calcium elevation is a sufficient trigger for ATP secretion from epithelial cells and fibroblasts strongly supports the involvement of exocytosis
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New insights into secretion in epithelial cells
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Oxygen and the ocular lens

A key to understanding nuclear cataract?

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Myofilament lattice plasticity in airway smooth muscle

Our mechanical, energetic, and structural studies suggest that airway smooth muscles adapt to longer lengths by placing more contractile elements in series, that this filament­lattice plasticity is facilitated by thick-filament evanescence, which dissolves partially during relaxation, and that filament reformation is sufficiently rapid to account for the observed velocity slowing and some of the force rise during the onset of activation
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Eccentric exercise provides new insight into sensorimotor control of muscle

Uwe Proske answers some questions about a form of exercise that leaves us stiff and sore next day, and how a study of such exercise can be used to better understand muscle and its neural control
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Physiology in the extreme

What drives perfectly sane physiologists to leave the comfort of their home labs to travel across the world to hostile environments in pursuit of their particular holy grail? By day Stuart Egginton is a Reader in Cardiovascular Physiology at the University of Birmingham, living the sort of academic existence that most of us would recognise. But from time to time he ups sticks and takes off for Antarctica. Thelma Lovick tries to find out why
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