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  • Spring 2006 - Issue Number 62
  • Spring 2006 - Issue Number 62

Below are the feature articles from Physiology News Issue 62, Spring 2006.

To read the full articles please download the issue.

  • Features

Physiology in the extreme

Thelma Lovick talked to another intrepid physiologist who takes his science into the extreme. Below, John Coote, Professor Emeritus in the Division of Neuroscience at the University of Birmingham, shares some of his experiences of doing physiology in the extreme environment encountered at high altitude
  • Features

Light up the signal fires – imaging calcium’s protein partners
  • Features

A racing start for the heart in exercise

At the onset of exercise the heart rate changes within one second to bring about a 25% increase in the heart rate, but what initiates these changes? Valerie Gladwell takes a closer look at the mechanisms involved, focusing on how feedback from the muscle alters the heart rate via cardiac vagal activity

  • Features

Calcium signalizing in developing mouse skeletal muscle fibres

Mice are born immobile and develop the ability to move over the first 2-3 weeks of life. Here Carlo Caputo and co-workers explore the underlying processes in skeletal muscle

  • Features

Vagal nociceptors in the oesophagus

Nociceptors, in Sherrington’s classic definition, are now exactly one hundred years old, but they keep turning up in new places. Here Marian Kollarik and Bradley Undem describe one example

  • Features

Dying for a good night’s sleep

Obstructive sleep apnoea, characterised by excessively loud snoring is not only embarrassing for the patient who falls asleep in public but has much more serious consequences – an increased risk of cardiovascular morbidity and mortality

  • Features

Ca2+ sparks – SOS signals of struggling muscle

Ca2+ sparks are rare in mammalian skeletal muscle under physiological conditions. Our recent studies reveal an important role for mitochondria in suppression of these localized Ca2+ signals

  • Features

Sympathetic nerve activity and cardiac output: an integrated balance with implications for blood pressure regulation

Sympathetic vasoconstrictor nerves have an important role in blood pressure regulation in humans via control of peripheral vascular resistance. Recent findings of a balance between cardiac hemodynamics and control of sympathetic activity at rest provide insight into integrated mechanisms of blood pressure regulation in individuals with widely varying sympathetic activity

  • Features

A new muscle sense?

Uwe Proske proposes that, whenever movement of our limbs is accompanied by an effort sensation, this information can be used by the brain to determine the location in space of the limbs

  • Features

Multimerisation – an only transporter is a lonely transporter
  • Features

How ion channels and transporters affect metastasis

Cell migration is an important mechanism in metastasis. Ion transporters such as the Na+/H+ exchanger NHE1 control migration of tumour cells by, among other things, modulating cell adhesion. NHE1 creates a pH nanoenvironment at the cell surface that allows a coordinated formation and release of cell-matrix contacts during cell migration
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