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  • Spring 2009 - Issue Number 74
  • Spring 2009 - Issue Number 74

Below are the feature articles from Physiology News Issue 74, Spring 2009.

To read the full articles please download the issue.

  • Features

Survival by downsizing: N-terminal truncation of cardiac troponin T increases heart efficiency during energetic crisis

An example of molecular evolution that adds modulatory structures in proteins is the N-terminal variable region of troponin T in the regulatory system of striated muscle. Recent studies have demonstrated that the N-terminal segment of cardiac troponin T can be selectively removed by restricted proteolysis during myocardial adaptation to energetic crisis. By reducing the velocity of contraction and elongating the time of ventricular ejection, this mechanism suggests a novel approach to developing treatment for congestive heart failure
  • Features

When motoneurons get ready: new insights into motor preparation

Advance information about forthcoming motor actions helps to prepare for rapid movement execution by triggering changes in neuronal activity a few hundreds of milliseconds before a movement is actually performed. These preparatory processes have been found to occur at many levels in the motor system, from the motor cortex to the spinal cord. We recently obtained evidence that even motoneurons, which are the most peripheral components in the spinal cord, respond in this way to advance information
  • Features

Statistical methodology and reporting – the case for confidence intervals
  • Features

Negative consequences of physical inactivity on non-alcoholic fatty liver disease development

Leading a sedentary lifestyle is increasing the risk for development of non-alcoholic fatty liver disease (NAFLD) in westernized countries. Sudden cessation of physical activity appears to upregulate many processes known to initiate hepatic steatosis development
  • Features

Vascular adaptations and exercise training: how to convince your cardiologist that physiology is important
  • Features

Heart disease link to oxygen in the womb

Studies of chick embryos and babies in La Paz, the highest city in the world, are helping to uncover a link between low oxygen in the womb with fetal growth restriction and heart disease in later life
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