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  • Summer 2006 - Issue Number 63
  • Summer 2006 - Issue Number 63

Below are the feature articles from Physiology News Issue 63, Summer 2006.

To read the full articles please download the issue.

  • Features

Reduced mitochondrial efficiency: dysfunction or defence in ageing muscle?

Mitochondrial oxidative phosphorylation has been found to become less efficient with age in both mouse and human skeletal muscle. Here, David Marcinek explores mechanisms that can lead to either a protective or pathological effect of this uncoupling

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Cardiac channelopathies studied with the dynamic action potential clamp technique
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Granny’s going global…

Investigating the organisational and functional principles operating within the social brain involves establishing causative links between behaviour and multi-component neural systems. With the introduction of new techniques for monitoring brain activity, are we now advancing towards an understanding of how brain systems mediate social cognition? Alister Nicol and colleagues look at current strategies and some of the challenges lying ahead

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Developing insights into Purkinje cell maturation

Recent evidence reveals a temporal correspondence between the maturation of spike output properties and cell structure during postnatal Purkinje cell development, which further parallels the development of anatomical, synaptic and behavioural indices of cerebellar maturation

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Bursting with currents

Vasopressin secretion varies with serum osmolality. We have identified a new osmosensitive current that may alter the firing patterns of the cells that release this important hormone

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Erythropoietin controls ventilation in hypoxia

The presence of erythropoietin in blood and brain increases the ventilatory response of mice exposed to oxygen deprivation. Expression of the Epo receptor in the respiratory centre as well as in the carotid bodies suggests that Epo controls the hypoxic ventilatory response at the central (brainstem) and peripheral (carotid body) level

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Muscle mass at the top: a likely role for fibre hyperplasia in humans

The extreme increase in muscle mass observed after heavy resistance training cannot be simply explained on the basis of muscle fibre hypertrophy, as is commonly assumed
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Working out aerobic fitness
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Targeted cell-based delivery of siRNA

Small interfering RNA (siRNA) is an ever more popular tool for silencing gene expression. But do experimenters always have to deliver siRNA directly into all the cells? Or can siRNAs pass from one cell to another via gap junctions? Ira Cohen and friends suggest that it all depends what connexins are around

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