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  • Winter 2003 - Issue Number 53
  • Winter 2003 - Issue Number 53

Below are the feature articles from Physiology News Issue 53, Winter 2003.

To read the full articles please download the issue.

  • Features

Pulmonary Na+ transport

The distal lung epithelia continually absorb Na from the lung lumen and this process ensures that water cannot accumulate in the alveolar region where it could endanger life by impairing oxygenation of the blood. In this article Stuart Wilson discusses some of the factors underlying the development and maintenance of this phenotype

  • Features

Managing magnitude and duration of amino acid availability as a strategy to optimize protein gain?

The effects of the pattern of amino acid availability on protein metabolism suggest that this factor might be used to optimize protein gain in various circumstances
  • Features

Brain food: the cerebral metabolic response to exercise

Following intense activation of the brain its carbohydrate uptake is enhanced, suggesting to Mads Dalsgaard that central fatigue relates to depletion of cerebral stores of glycogen
  • Features

How does your gut grow?

The presence of food in the gut is a powerful driver of cell (and crypt) reproduction
  • Features

How mutations in myosin affect the heart

Half of all cases of familial hypertrophic cardiomyopathy are associated with a mutation in myosin. Here, Sarah Calaghan and Michelle Peckham discuss whether it is a loss or a gain of function of mutant myosin that results in hypertrophy of the heart

MGF: a local growth factor or a local tissue repair factor?

Combining physiological and molecular biology methods have indicated how a factor expressed by stressed muscle induces local muscle fibre repair and adaptation

  • Features

Investigating schemes for control of human movement

Mark Hinder and Theodore Milner’s recent investigations favour control by formation of an internal dynamics model over equilibrium point control
  • Features

Ernest Starling (1866–1927)
  • Features

Brain glycogen re-awakened

Why concern ourselves with an apparently inconsequential compound, asks Angus Brown
  • Features

A new window on sympathetic neuromuscular transmission

Seeing ATP and noradrenaline at work in small arteries and vas deferens. W Gil Wier explains
  • Features

Kidney development – consequences of disruption

Strong evidence now indicates that kidney development can be disrupted by an adverse intrauterine environment at a very early, preglomerular stage, and this may programme hypertension in the adult

  • Features

Breathing powerfully modulates human vagal and sympathetic motoneurone responsiveness

Fluctuations of vagal and sympathetic motoneurone membrane potentials alter their susceptibility to stimulatory inputs and thereby order the timing of efferent neural outflow from the human central nervous system, writes Dwain Eckberg

  • Features

Limits to human performance caused by muscle fatigue

David Allen and colleagues describe the mechanisms of fatigue in muscles and show how they differ in various types of activity
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