Sodium Channels in Nociceptive Neurones – Jim Elliott (p.6)

Kostyuk and co-workers proposed nearly twenty years ago that rat sensory neurones express two different sodium currents (INa)- One was a “classical” current readily blocked by tetrodotoxin (TTX). The other had different electrophysiological properties and was also resistant to TTX block (Kostyuk et al, 1981).