Physiology News Magazine

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The Funny Current – Dario di Francesco (p. 4)

The Funny Current – Dario di Francesco (p. 4)

“Look! Isn’t it funny?” In late ’78, as a postdoc in Denis Noble’s laboratory in Oxford, I was sitting at the voltage-clamp setup in the (ex) Ophthalmology room, painfully extracting data from a tiny piece of tissue isolated from rabbit sinoatrial node (SAN), and when I turned around to ask Hilary Brown (middle in Fig. 1) what she thought of the odd inward current that developed during hyperpolarizating steps, I did not know we were dubbing a newly discovered channel for good.

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