Proceedings Abstracts of The Physiological Society

Heart & Cardiac Muscle

Decreased fatty acid uptake and metabolism during acute and chronic cardiac ischemia are mediated by different mechanisms

K. Pates1, J. Griffin2, J. Luiken3, K. Clarke1, L. Heather1

Proc Physiol Soc 29 (2012)

Modification of PPAR?? activity is detrimental to cardiac function during chronic hypoxia - critical role of PPAR?? on cardiac substrate metabolism

A. Abd Jamil1, M. Cole1, L. Heather1, R. Evans1, E. Sutton1, K. Clarke1

Proc Physiol Soc 29 (2012)

Assessment of magnitude and dispersion of epicardial conduction velocity in Langendorff perfused murine hearts

Y. Zhang1,2, G. D. Matthews2, L. A. Black1, C. L. Huang2, M. Lei1, J. Fraser2

Proc Physiol Soc 28 (2012)

Age-associated alterations in intracellular calcium handling within the sinoatrial node

F. S. Hatch1, M. K. Lancaster2, S. A. Jones1

Proc Physiol Soc 28 (2012)

In cardiac ventricular myocytes correction of severe leak from the sarcoplasmic reticulum increases the amplitude and the rate of decay of the systolic calcium transient

R. Sankaranarayanan1, Y. Li1, D. Greensmith1, A. Trafford1, L. Venetucci1, D. Eisner1

Proc Physiol Soc 28 (2012)

The capacity to modulate ryanodine receptor channel gating by FK506-binding proteins is contained within three amino acid residues

E. Galfre1, E. Venturi1, S. J. Pitt1, S. Bellamy1, R. B. Sessions1, R. Sitsapesan1

Proc Physiol Soc 28 (2012)

Popdc1 and Popdc2 deficiency results in an impaired response to β-adrenergic signalling

S. Simrick1, C. Terracciano2, T. Brand1

Proc Physiol Soc 28 (2012)

Interfering with lysosomal function in atrial and ventricular myocytes reduces the response to isoprenaline

R. A. Bayliss1, E. L. Bolton1, D. Bloor-Young1, G. Churchill1, A. Galione1, D. A. Terrar1

Proc Physiol Soc 28 (2012)

The role of cGMP dependent nitric oxide signalling on cardiac repolarisation in adult guinea pig ventricular myocytes

R. E. Caves1, K. E. Brack2, A. Ng2, J. S. Mitcheson1

Proc Physiol Soc 28 (2012)

The arrhythmic effect of nifedipine mediated via the low affinity β1-adrenoceptor

C. L. Sam1,2, T. B. Bolton2, I. T. Piper1, N. S. Freestone1

Proc Physiol Soc 28 (2012)

The time course and magnitude of conduction velocity response to raised cyclic adenosine monophosphate in the intact rat heart

A. Campbell1, F. Burton1, G. Baillie1, G. L. Smith1

Proc Physiol Soc 28 (2012)

Mismatch between simulations and action potential prolongation in Timothy Syndrome

G. Bett1,2, S. Fernandez3, A. Lis2, Q. Zhou4, R. L. Rasmusson2,4

Proc Physiol Soc 28 (2012)

The effects of the Short QT Syndrome on electrical and mechanical function of the heart: insights from modelling

I. Adeniran1, J. C. Hancox2, H. Zhang1

Proc Physiol Soc 28 (2012)

May the transient outward current 4-aminopyridine sensitive contribute to the "plateau" of the action potential in mouse sinoatrial node?

M. Gonotkov1, E. Lebedeva1, V. Golovko1

Proc Physiol Soc 28 (2012)

Stimulation of ICa by protein kinase A is facilitated by caveolin-3 in rat cardiac ventricular myocytes

S. Bryant1, T. Kimura-Wozniak1, C. Orchard1, A. James1

Proc Physiol Soc 28 (2012)

Atrial remodeling causes different cellular Ca2+ handling in pigs with hypertension versus atrial fibrillation

G. Jin1, F. R. Heinzel1, P. Wakula1, P. Schoenleiter1, S. Radulovic1, M. Schwarzl1, H. Post1, B. Pieske1, G. Antoons1

Proc Physiol Soc 28 (2012)

Effects of phosphodiesterase type 5 inhibition on intracellular calcium handling and its implications for cardioprotection and antiarrhythmogenesis

D. C. Hutchings1, M. Lawless1, D. A. Eisner1, A. W. Trafford1

Proc Physiol Soc 28 (2012)

Modulation of ryanodine receptor open probability has no maintained effect on the amplitude of systolic calcium release in sheep or dog ventricular myocytes

D. J. Greensmith1, A. W. Trafford1, K. M. Dibb1, D. A. Eisner1

Proc Physiol Soc 28 (2012)

Wheat germ agglutinin staining of rabbit cardiac myocytes

H. C. Gadeberg1, C. Kong1, M. B. Cannell1, A. F. James1

Proc Physiol Soc 28 (2012)

Action potential clamp and pharmacological study of the gain-of-function T618I hERG channel pore mutant

A. El Harchi1, D. Melgari1, H. Zhang2, J. Hancox1

Proc Physiol Soc 28 (2012)

Remote ischaemic conditioning attenuates endothelin-1 induced hypertrophic response in rat cardiomyoblasts

A. P. Vanezis1, S. A. Edroos1, N. J. Samani1, G. C. Rodrigo1

Proc Physiol Soc 28 (2012)

Comparative modulation of rabbit atrioventricular node cell K+currents by endothelin-1 and phenylephrine

S. C. Choisy1, A. F. James1, J. C. Hancox1

Proc Physiol Soc 28 (2012)

Effect of global and local changes of intracellular pH on spontaneous Ca2+ waves in rat ventricular myocytes

K. L. Ford1, E. L. Moorhouse1, M. Bortolozzi2, R. D. Vaughan-Jones1

Proc Physiol Soc 28 (2012)

Atrioventricular nodal dysfunction in the monocrotaline rat model of pulmonary arterial hypertension

I. P. Temple1, G. M. Quigley1, O. Monfredi1, T. T. Yamanushi1, V. S. Mahadevan1, G. Hart1, M. R. Boyett1

Proc Physiol Soc 28 (2012)

Diminished SR function and adrenergic response co-associate in the ageing sinoatrial node

F. S. Hatch1, M. K. Lancaster2, S. A. Jones1

Proc Physiol Soc 28 (2012)

The effects of sympathetic nerve stimulation on cardiac ventricular electrophysiology in long QT syndrome 1 in the innervated guinea pig heart

K. E. Brack1, A. Gupta1, G. Ng1

Proc Physiol Soc 28 (2012)

Sodium-dependent background current in cells from the rabbit atrioventricular node

H. Cheng1, C. H. Orchard1, M. R. Boyett2, J. C. Hancox1

Proc Physiol Soc 28 (2012)

Pro-arrhythmic effects of the electrical coupling between fibroblasts and myocytes in mouse atrium

W. Shen1, X. Wang2, M. Lei3, H. Zhang1

Proc Physiol Soc 28 (2012)

Ionic mechanisms underlying the difference in the pacemaking action potentials of the rabbit and the murine sinoatrial node cells

R. Wang1, X. Wang2, M. Lei3, M. Boyett3, H. Zhang1

Proc Physiol Soc 28 (2012)

Development of a one-dimensional whole heart model for rabbit

S. J. Castro1, J. Higham1, A. V. Holden2, M. R. Boyett1, H. Zhang1

Proc Physiol Soc 28 (2012)

A methodological approach for the study of the cytoarchitecture of the sarcotubular membrane system in cardiac health and disease

C. Pinali1, A. W. Trafford1, A. Kitmitto1

Proc Physiol Soc 28 (2012)

Autonomic regulation in the 3D human atria: insights from the development of a new computational model of the 3D human atria

M. A. Colman1, M. Boyett1, H. Zhang1

Proc Physiol Soc 28 (2012)

Computational evaluation of heart failure-induced ionic channel remodeling on the transmural heterogeneity in the canine ventricle and Purkinje fibers

C. Li1, H. Zhang1

Proc Physiol Soc 28 (2012)

Ionic mechanisms underlying upright ECG T-wave in a 3D anatomical and electrophysiological model of rabbit ventricles

S. J. Castro1, J. Higham1, A. V. Holden2, M. R. Boyett1, H. Zhang1

Proc Physiol Soc 28 (2012)

The origin of cardiac excitation in zebrafish

K. L. Poon1,2, J. D. Liu3, M. Liebling4, I. Kondrychyn2, P. Kohl5,6, T. A. Quinn5,6, D. Stainier3, T. Brand1, V. Korzh2

Proc Physiol Soc 28 (2012)

Computational evaluation of the pro-arrhythmic effects of KCNH2 channel current-activator in serum in failing human ventricles

C. Li1, I. Adeniran1, J. Hancox2, H. Zhang1

Proc Physiol Soc 28 (2012)

The importance of the sarcoplasmic reticulum for the influence of I(f) carried by hyperpolarization-activated cyclic nucleotide-gated ion channels on pacemaker activity in mouse sino-atrial node

I. Nazarov1, T. Thevarajan1, R. Bayliss1, D. A. Terrar1

Proc Physiol Soc 28 (2012)

Transmural gradients in excitation-contraction coupling in ventricular myocytes isolated from aged failing hearts

E. F. Bode1, M. A. Horn1, D. A. Eisner1, A. W. Trafford1

Proc Physiol Soc 28 (2012)

Role of MKK7 in hypertrophic cardiac diseases

S. K. Chowdhury1, X. Wang1

Proc Physiol Soc 28 (2012)

Dysfunction of the Purkinje fibres underlies delayed interventricular conduction in heart failure

J. Yanni1, X. Cai1, C. Jones1, A. Corno1, R. Hutcheon1, O. Monfredi1, G. Hao1, J. Jarvis1, H. Dobrzynski1, G. Hart1, M. R. Boyett1

Proc Physiol Soc 27 (2012)

Exercise rectifies contractile dysfunction in heart failure by activating CaMKII

A. S. Johnston1, K. McGlynn1, A. Henry1, M. Dunne1, G. L. Smith1, O. J. Kemi1

Proc Physiol Soc 27 (2012)

Oral simvastatin dosing in rat enhances myocardial nitric oxide synthase expression, troponin I phosphorylation and cardiomyocyte lusitropy

D. A. MacDougall1, A. L. Longster1, K. E. Porter1, S. C. Calaghan1

Proc Physiol Soc 27 (2012)

The nitric-oxide dependent antifibrillatory effects of vagus nerve stimulation in the rabbit ventricle involve cGMP-dependent mechanisms

J. Winter1, A. Gupta1, K. E. Brack1, G. Ng1

Proc Physiol Soc 27 (2012)

Wenckebach rhythms during human atrial tachyarrhythmias: role of AV nodal recovery and dual pathway physiology

M. Masè1, L. Glass2, M. Disertori3, F. Ravelli1

Proc Physiol Soc 27 (2012)

Calcium-independent shortening of resting sarcomere length in rat failing right ventricular myocytes

E. Fowler1, D. S. Steele1, E. White1

Proc Physiol Soc 27 (2012)

High speed acquisition of sarcomere length in Langendorff-perfused hearts using arbitrary plane 2-photon microscopy

R. B. Burton1, A. Corbett2, E. J. Botcherby2, C. W. Smith2, T. Wilson2, G. Bub2

Proc Physiol Soc 27 (2012)

In the presence of ??-stimulation, chronic myocardial infarction promotes atrial fibrillation and decreases atrial L-Type Ca2+ current

S. Kettlewell1, F. L. Burton1, G. L. Smith1, A. J. Workman1

Proc Physiol Soc 27 (2012)

Histological characterisation and functional effects of ganglionic plexus activation in the rabbit heart

K. E. Brack1, M. Shotton1, J. H. Coote2, B. Grubb1, G. Ng1

Proc Physiol Soc 27 (2012)

Marked remodelling of the sinoatrial node underlies bradycardia in rabbits with congestive heart failure

X. J. Cai1, J. Yanni1, C. B. Jones1, O. Mondredi1, A. F. Corno1, R. C. Hutcheon1, G. L. Hao1, H. Dobrzynski1, M. R. Boyett1, G. Hart1

Proc Physiol Soc 27 (2012)

Neuronal nitric oxide synthase mediates angiotensin II impairment of fatty acid-dependent contraction by targeting transglutaminase II in rat left ventricular myocytes

Y. Zhang1, C. Jin1, E. Jeong2, J. Jang1, I. Kim2, S. Kim1

Proc Physiol Soc 27 (2012)