Muscular dystrophy (MD) encompasses inherited myopathies characterised by progressive skeletal and cardiac muscle degeneration, chronic inflammation and metabolic dysfunction. Whilst much of the research spanning the previous three decades has focussed on identifying and developing cures and pharmacological therapies for these conditions, very few have translated from pre-clinical models and even successful therapies are rarely approved for NHS use due to cost constraints. Therefore, it is important that easy-to-implement, cost-effective non-pharmacological interventions are developed which can improve, or offset deteriorations in, skeletal muscle strength and function in these conditions and thereby improve quality of life further into disease progression. One factor which is easily modifiable is diet, with previous dietary interventions showing benefits to skeletal muscle size, strength and function in non-dystrophic clinical conditions. Importantly, given the progressive nature of muscular dystrophy, diet modulation may be of even greater importance given the potential inability of those with dystrophy to complete regular exercise/activity later in disease progression. However, currently very little is known about the habitual dietary practices of adults living with muscular dystrophy and whether such habits are associated with skeletal muscle size, strength and function as well as subjective measures such as quality of life, ability to complete activities of daily living and fatigue. This talk will focus on recent data from our group with explores these relationships across a relatively large cohort of adults living with various dystrophinopathies before discussing planned future dietary interventions based off these findings.
Dietary Manipulations for Health and in the Prevention and Management of Disease 2026 (Manchester Metropolitan University, UK) (2026) Proc Physiol Soc 68, SA09
Research Symposium: Exploring the relationships between dietary habits, physical function and quality of life in adults living with muscular dystrophy
Nathan Hodson1
1University of Birmingham UK
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Where applicable, experiments conform with Society ethical requirements.