Since use of chemical drugs for relief of pain have many side effects, today medical plants are very noticeable. Previous findings indicate that Coriandrium Sativum (CS) modulates pain in both animal and human. The present work investigated the effects of CS seed on acute pain using hot plate and tail flick models. Albino mice (20-30 gram) were used for this study. Aqueous extract of CS seed was injected in doses of 100 and 200 milligram per kilogram 30 min before test. Then the analgesic effect of the drug on acute pain was evaluated using Hot plate and Tail flick models. Results indicated that CS has analgesic effect pain in both doses in both models and higher dose of the drug was more effective (P<0.01). Finding above showed that CS can modulate acute pain. Further research is required to determine the mechanisms by which CS has an inhibitory effect on pain sensation.