To investigate the effect of aging on various physiological parameters related to inflammation in the pancreas obtained from male, old and young senescence prone (SAMP8) mice and the influence of growth hormone (GH) treatment on the same parameters in the old group. Nineteen animals were used, divided into three groups: old (10 months), young (2 months), old GH-treated sc with 2mg/kg GH. All animals were treated for one month with GH or vehicle. The group of young animals was used as control. The expression of interleukin 4 (IL4), interleukin 10 (IL10), Interleukin 1β (IL1β), Interleukin 2 (IL2), Interleukin 6 (IL6), Tumor Necrosis Factor α (TNFα) and Monocyte chemoattractant protein 1 (MCP1) was determined by specific ELISA methods in homogenates of pancreas. Anti-inflammatory cytokines like IL10 showed a significant decrease in older individuals whereas IL4 did not showed differences with young mice. Aging significantly increased the levels of pro-inflammatory cytokines like IL1β, IL2, IL6, TNFα. But no differences in MCP1 were observed. Administration of GH to old male mice significantly increased the levels of IL4 and IL10. GH treatment reduced also significantly IL1β, IL2, IL6, TNFα and MCP1. Aging leads to an increase of inflammatory processes in the pancreas. The administrations of sustitutive hormonal therapy with GH inhibited the production of pro-inflammatory cytokines and increased anti-inflammatory cytokine production.