Noncoding RNAs including microRNAs (miRNAs) and long noncoding RNAs (lncRNAs) regulate a substantial fraction of the genome and most cellular functions in health and disease. It has been shown that noncoding RNAs are both diagnostically and therapeutically of highest relevance. In this talk, their role as potential players in different vascular cells (e.g. endothelial and smooth muscle cells) will be discussed. This includes the role of anti-angiogenic and pro-apoptotic miR-24 for outcome after ischemic cardiac disease in small and large animal models. Additionally, the importance of hypoxia-related lncRNAs will be highlighted to introduce new aspects of regulatory RNA biology.
Physiology 2015 (Cardiff, UK) (2015) Proc Physiol Soc 34, SA020
Research Symposium: Noncoding RNAs in vascular cells and implications for cardiac disease
J. Fiedler1
1. Hannover Medical School, Hannover, Germany.
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Where applicable, experiments conform with Society ethical requirements.