Serum adiponectin concentration is inversely associated with leptin and insulin concentration. There is little paucity of information in the literature on the adipokine levels and regulation by resveratrol in cholesterol diet-fed animals. Thirty rabbits were randomly divided into six groups, each of five animals: Group 1 = control (C), Group 2 = cholesterol diet (CD) only, Group 3 = resveratrol 200 mg/kg (R200), Group 4 = resveratrol 400 mg/kg (R400), Group 5 = CD + R200 and group 6 = CD + R400. The preparations were administered for 8 weeks of experimental protocol. Weight and blood glucose level were measured on week zero and the 8th week of the treatment. At the end of the study period, the rabbits were placed under light anaesthesia (ketamine) to remain unconsciouse. Blood sample of about 3ml was drawn via cardiac puncture for serum extraction which were evaluated for serum concentration of metabolites assays (adiponectin, leptin and insulin). Blood glucose level and body weight were significantly higher in CD group compared to groups that received resveratrol supplement. Serum adiponectin significantly (P < 0.05) increased in resveratrol + CD groups, compared to CD group only. Leptin and insulin significantly (P < 0.05) decreased in CD groups co-administered with resveratrol, compared with CD group only. In conclusion, the increase in adiponectin level and decrease in leptin and insulin level following resveratrol administration elucidated the therapeutic potential of resveratrol, despite cholesterol diet consumptions.