• 07 Jul 2019
  • Aberdeen Exhibition and Conference Centre, Aberdeen, UK

Cellular mechanisms of anti-cancer induced cardiotoxicity

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This satellite symposium, Cellular mechanisms of anti-cancer induced cardiotoxicity, highlights novel strategies to prevent, or reduce, cardiotoxicity resulting from cancer treatment so as to ensure the best cancer care possible.

 

Symposium organisers

Organiser: Susan Currie, University of Strathclyde, Glasgow, UK
Co-organiser: Margaret Cunningham, University of Strathclyde, Glasgow, UK

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Sunday 7 July 2019

Registration and coffee

Welcome

Session 1

Chair: Susan Currie, University of Strathclyde, Glasgow, UK

09:40 Detoxifying doxorubicin with semi-rational modifications
Jacques Neefjes, Leiden University, Netherlands
10:25 Cardiotoxicity of anti-cancer therapy: clinical context and translational gaps
Ninian Lang, University of Glasgow, UK

Refreshments and posters

Session 2

Chair: Margaret Cunningham, University of Strathclyde, Glasgow, UK

11:20 MAPK signalling in sunitinib-induced cardiotoxicity
Helen Maddock, Coventry University, UK
12:05 Activation of RyR2 by class I kinase inhibitors
Niall MacQuaide – University of Glasgow, UK
12:30 The crosstalk between cardiac and inflammatory cells: functional role in cardiotoxicity
Jessica Gambardella – University of Salerno, Italy

Lunch and posters

Session 3

Chair: Susan Currie, University of Strathclyde, Glasgow, UK

14:00 hiPSC-CMs in disease modelling and drug screening: characteristics of repolarisation reserve and Ca2+ dynamics
Jussi Koivumaki, Tampere University, Finland
14:45 Receptor tyrosine kinase inhibitors impact on cardiac stem cells and cardiac function
Andrew Smith, University of Leeds, UK
15:10 Refreshment break
15:35 The vascular protective effect of statins on doxorubicin-induced cardiotoxicity
Michael Cross, University of Liverpool, UK 
16:00 Microparticles as biomarkers and mediators of endothelial cell injury in VEGF inhibitor-treated cancer patients
Karla Neves, University of Glasgow, UK 

Drinks, posters and networking

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You must be registered for Physiology 2019 to register for the ‘Cellular mechanisms of anti-cancer induced cardiotoxicity’ Satellite Symposium. To register for Physiology 2019 click here.

 

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Travel

For information on travelling to Aberdeen, please see Visit Aberdeen.

Physiology 2019 will be hosted at the Aberdeen Exhibition and Conference Centre, Exhibition Ave, Bridge of Don, Aberdeen AB23 8BL. The AECC is the largest convention centre in northern Scotland, hosting 600 events and welcoming over 300,000 visitors each year.

AECC sits right next to the A90. It’s only a 15-minute taxi ride from Aberdeen railway and bus stations in the city centre.

By Bus

 

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Summary

Cardiovascular disease and cancer are the leading causes of death in the industrialised world. Anti-cancer therapies have dramatically improved over recent years with increased patient survival rates following diagnosis. Kinase inhibitors in particular have had a major impact on cancer patient survival. However, a number of these agents have been reported to cause serious adverse effects on cardiac function, leading to increased numbers of cancer patients with cardiovascular complications that can, in some cases, lead to death. The true extent of the overall risk to cancer patients is unknown and the underlying mechanism(s) responsible for the cardiotoxic effects remain to be fully identified. Strategies to prevent or mitigate cardiotoxicity resulting from cancer treatment are urgently needed to ensure the best cancer care possible. Future management of anti-cancer drug-related cardiotoxicity will rely on improved understanding of the cellular effects of these agents in the heart. This, combined with improved biomarker identification along with cardiac imaging for monitoring purposes, will be crucial in an overarching strategy to design effective targeted cardioprotective agents. This symposium will be a forum to bring together basic scientists, cardiologists and oncologists to present recent findings that will work towards this overall goal. Ultimately collaboration across these disciplines will be essential for promotion of evidence-based research that can relate to clinical practice in the area of anti-cancer cardiotoxicity.

The key aims of the symposium will be to inform upon:

(i) Novel mechanisms of anti-cancer induced cardiotoxicity that may include off-target effects

(ii) Intervention strategies that could reduce/reverse cardiotoxic effects

(iii) Novel drug design that can improve on current therapeutics

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