• 07 Jul 2019
  • Mercure Aberdeen Ardoe House Hotel, Aberdeen, UK

Physiology of obesity and diabetes

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This satellite symposium, Physiology of obesity and diabetes, shares insights from breaking research advances relevant to human obesity and type 2 diabetes from the basic science and clinical realms to better understand metabolic health.

 

Symposium organisers

Organiser: Lora Heisler, University of Aberdeen, UK
Co-organisers: Peter Aldiss, University of Birmingham, UK
Daniel Brayson, University College London, UK
Jo Lewis, University of Cambridge, UK

Sponsors

This satellite symposium is supported by Elsevier,  The British Heart Foundation and British Society for Neuroendocrinology. 

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Sunday 7 July 2019

Registration and tea and coffee

Welcome

Keynote and Session 1

Chairs: Peter Aldiss, University of Birmingham and Jan Nedergaard, University of Stockholm

09:00 Opening Keynote: Genetic contributions of obesity
Giles Yeo, University of Cambridge, UK
09:45 Genetic determinants of adipogenesis
Justin Rochford, University of Aberdeen, UK
10:15 Regulation of food intake by brainstem astrocytes
Kate Ellacott, University of Exeter, UK

Coffee break

Session 2

Chairs:  Dr Jo Lewis, University of Cambridge and Dr Gisela Helfer, University of Bradford

11:00 Impact of peripheral regulators of energy balance on the reward system.
Suzanne Dickson, University of Gothenburg, Sweden
11:30 Impact of activity and inactivity on body weight
Jason Gill, University of Glasgow, UK
12:00 FGF21 - a selective inhibitor of sugar and alcohol appetite
Susanna Søberg, Novo Nordisk Foundation Center for Basic Metabolic Research, Copenhagen, Denmark (EYES invited talk)
12:15 Functional interrogation of caudal brainstem circuits modulating appetite
Giuseppe D’Agostino, University of Aberdeen, UK

Lunch

Obesity, Diabetes and Cardiovascular Disease Data Blitz

Chairs: Ian Salt, University of Glasgow and Rebecca Dumbell, MRC Harwell

AMP-activated protein kinase (AMPK) activator R481 improves the counterregulatory response to hypoglycaemia by amplifying glucagon release in healthy rats
Craig Beall, University of Exeter
A novel protein regulator of adipogenesis
Pola Verschoor, University of Aberdeen
Effects of two-weeks of time restricted feeding on basal and postprandial metabolism in healthy men
Robert Jones, University of Nottingham
Phenotypic screening reveals diverse gene expression signatures between different browning agents using high throughput Openarray qPCR in human adipocytes
Graeme Davies, AstraZeneca
Repeated hypoglycaemia attenuates cFos expression in corticotrophin-releasing hormone neurons of the paraventricular nucleus of hypothalamus
Adhithya Sankar, University of Manchester
Impact of carotid sinus nerve resection on metabolic dysfunction induced by ageing and by long-term hypercaloric diet consumption in rats
Joana F. Sacramento, Universidade Nova de Lisboa
Insulin sensitivity was enhanced by Ocimum gratissimum leaf extract in Wistar rats with dexamethasone-induced metabolic syndrome
Shehu-Tijani Shittu, University of Ibadan
Inhibition of chemerin/CMKLR1 axis in the hypothalamus reduces body weight and food intake
Gisela Helfer, University of Bradford
Blueberry extract supplementation prevents diet induced obesity in C57BL/6 mice fed a high-fat diet
Alina Zitskaja, Rowett Institute
Osteoblast-specific Enpp1 deficiency engenders increased bone mass and insulin resistance
Fiona Roberts, University of Edinburgh

Session 3

Chairs:  Barbara Cannon, Stockholm University and Pablo Martinez de Morentin, University of Aberdeen

14:30 "Insulin resistance" and major disease - monogenic lessons
Rob Semple, University of Edinburgh, UK
15:00 New targets for the treatment of type 2 diabetes
Mirela Delibegovic, University of Aberdeen, UK
15:30 Islet (beta-cell) heterogeneity is essential for insulin secretion
Daniela Nasteska, University of Birmingham, UK
15:45 Importance of GLP-1 axis post-bariatric surgery
Pierre Larraufie, University of Cambridge, UK

Coffee break

Session 4

16:30 Gut peptide combination therapy for the treatment of human obesity
Tricia Tan, Imperial College London, UK
17:00 New medications in the pipeline for obesity and type 2 diabetes treatment
Jacqueline Naylor, MedImmune, UK
17:30 Molecular Metabolism Early Career Researcher Prize
Rebecca Dumbell, MRC Harwell Institute
17:50 Closing Keynote: Molecular mechanisms of islet function
Lori Sussel, Barbara Davis Center for Diabetes, Colorado, USA

Closing remarks

Poster Session

Dinner and networking

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You must be registered for Physiology 2019 to register for the ‘Physiology of Obesity and Diabetes’ satellite symposium.

This symposium is now sold out. Please take a look at the four other satellite symposia to see if any others are of interest.

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Location

The ‘Physiology of obesity and diabetes’ satellite sympsoium will be held at the Mercure Aberdeen Ardoe House Hotel, South Deeside Road Blairs, Aberdeen, AB12 5YP.

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Summary

Obesity is an increasingly common disorder of energy homeostasis and has become a leading cause of type 2 diabetes, cardiovascular disease, human morbidity and mortality worldwide. Exciting new scientific discovery continues to propel the understanding of the molecular, cellular, and neural mechanisms underlying the control of metabolic health. Dysregulation of these and other processes underpin the development and progression of obesity, type 2 diabetes and cardiovascular disease. This symposium will bring together breaking research advances from the basic science and clinical realms with the objective of sharing novel insights relevant to human obesity, type 2 diabetes and cardiovascular disease. Specifically, the symposium seeks to integrate existing knowledge with novel discoveries on appetite, cognitive drivers of feeding behaviour, the gut-brain axis, the neurobiology of ingestive behaviour and energy expenditure, adipogenesis and lipolysis, glucose sensing and glycaemic control, cardiovascular disease and the genetics of obesity and type 2 diabetes. Several new areas will also be addressed, including state-of-art technologies for neuroscience and physiological research, ageing, anorexia and metabolic resilience.

The primary goal of this symposium is to provide the most cutting-edge research related to the control of body weight and glucose homeostasis. The maintenance of stable body weight involves the biological process energy homeostasis that matches cumulative energy intake to expenditure. The discovery of critical integrative systems that underpin energy homeostasis and glucose metabolism has important implications for the future of obesity and type 2 diabetes treatment. This symposium will highlight the latest advances in the cellular and molecular mechanisms whereby brain circuits modulating physiological appetite and the cognition of food intake are integrated with systems controlling gut function and insulin sensitivity. We will explore the cross-regulation of these circuits by adiposity- and nutrient-related signals.  The most recent advances on the impact of obesity on vascular health and function will discussed. New technologies propelling these discoveries and their clinical relevance will also be highlighted. The symposium will bring together early career and established researchers studying appetite, metabolism, body weight, glucose homeostasis and cardiovascular disease. Symposium participants will discuss the latest research along with future directions and perspectives

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