Glomerular Physiology & Pathophysiology
- 10:00 Modelling glomerular physiology using drosophila
- Paul Hartley, Bournemouth University, UK
- 10:30 The mechanobiology of podocytes in health and disease
- Paul Reynolds, University of St. Andrews, UK
- 11:00 Using multi-omics approaches to understand podocyte function
- Markus Rinschen, University of Cologne, Germany
- 11:30 PC08 Glomerular nephropathies in mice associated with VEGF splicing are ameliorated by SRPK1 inhibition
- Andrew Benest, Univeristy of Nottingham , UK
- 11:45 Q&A
Renal tubular transport
- 13:00 WNK/SPAK regulation of Na+ and K+ transport in the distal tubule
- Juliette Hadchouel, Université Paris Sud, France
- 13:30 Role of ENaC in hypertension and Na+ retention in proteinuria
- Boye Jensen, University of Southern Denmark, Denmark
- 14:00 Sex differences in renal transporters and electrolyte homeostasis: A female advantage?
- Alicia McDonough, University of Southern California, USA
- 14:30 PC02 GR activation stimulates NCC and determines diurnal rhythm of its phosphorylation
- Jessica Ivy, University of Edinburgh, UK
- 14:45 PC05 The physiological conundrum of inorganic phosphate stimulation of urinary ammonium excretion in the acidotic rabbit
- Patrick Walsh, RCSI Bahrain, Bahrain
The Kidney and Hypertension
- 15:30 The potassium switch in hypertension
- Paul Welling, University of Maryland, USA
- 16:00 The role of the circadian clock in hypertension
- Michelle Gumz, University of Florida, USA
- 16:30 Vascular biology of hypertension
- Rhian Touyz, University of Glasgow, UK
- 17:00 PC03 A role for male, but not female, macrophages in the clearance of endothelin-1
- Greg Sutton, University of Edinburgh, UK
- 17:15 PC12 GPR81 activation causes endothelin-1 dependent renal vasoconstriction
- Natalie Jones, University of Edinburgh, UK
For information on travelling to Aberdeen, please see Visit Aberdeen.
Physiology 2019 will be hosted at the Aberdeen Exhibition and Conference Centre, Exhibition Ave, Bridge of Don, Aberdeen AB23 8BL. The AECC is the largest convention centre in northern Scotland, hosting 600 events and welcoming over 300,000 visitors each year.
AECC sits right next to the A90. It’s only a 15-minute taxi ride from Aberdeen railway and bus stations in the city centre.
Organiser: Morag K Mansley, The University of Edinburgh, UK
Co-organiser: Robert W Hunter, The University of Edinburgh, UK
Renal physiology is flourishing in the UK and around the world. In recent years physiologists have made fundamental advances: we now know the molecular basis of oedema formation in nephrotic syndrome, how renal sodium and potassium excretion can be controlled independently and how glomerular capillary permeability is regulated. We are learning much about the influence of the kidney on whole-organism physiology, in particular blood pressure homeostasis and circadian physiology.
In the current era, we are also witnessing a flourishing bi-directional relationship between advances in clinical medicine and mechanistic research into basic renal physiology. The bench-to-bedside journey is exemplified by sodium glucose co-transporter inhibitors (SGLTi). The physiological actions of these agents were meticulously defined in animal models. Now they have been shown to delay progression of diabetic nephropathy in large-scale clinical trials, so that we now have the first new effective treatment for this common condition in 15 years. On the other hand, clinical and epidemiological observations have thrown up fundamental physiological questions that have been answered in the laboratory (for example work exploring the consequences of pathological ApoL1 variants for podocyte biology).
This symposium aims to bring together scientists with a shared interest in renal physiology. We will focus on recent advances in three areas:
i) glomerular physiology & pathophysiology
ii) renal tubular transport
iii) the kidney and hypertension
We aim to explore recent advances in basic renal physiology and consider how these are relevant for human kidney disease. We are delighted to welcome leading scientists from around the world to talk about their work alongside conference delegates. We hope that this will provide a vibrant forum for senior and early career researchers to discuss the hot topics in renal physiology today.