We are recruiting a highly motivated postdoctoral researcher to join a multidisciplinary programme investigating the mechanisms that drive the progression and resolution of metabolic dysfunction–associated steatohepatitis (MASH). This research integrates whole‑body metabolic phenotyping with cutting‑edge liver‑focused mechanistic studies to determine how hepatic metabolism, inflammation, and fibrosis respond to metabolic stress, weight loss, and weight regain.
A major focus of the role is understanding how extra‑hepatic tissues—particularly skeletal muscle—shape liver vulnerability and recovery. Changes in muscle mass, substrate utilisation, and endocrine output during weight loss and weight regain are likely to be key determinants of MASH outcomes, and the project provides a unique opportunity to dissect these interactions across cellular, organ, and whole‑body levels.
The researcher will work across rodent models of metabolic liver disease, ex vivo perfused liver systems, primary hepatocyte and hepatic stellate cell cultures, and single‑cell multi‑omics to map the pathways that govern steatosis, fibrotic remodelling, and liver resilience.